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Original Articles

Paraquat-induced Thrombotic Microangiopathy: The Pathophysiology in Hyperacute Paraquat Poisoning Deaths

Issue: 
DOI: 
10.7727/wimjopen.2018.141
Pages: 
72-6
Synopsis: 
The underlying pathophysiological mechanism of hyperacute death in paraquat suicide involves thrombotic microangiopathy.

ABSTRACT

Accepted: 
November 23, 2018
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Age, Body Mass and Physical Activity Determinants of Facial Acne Severity among Southern Nigerian Adolescents and Young Adults

Issue: 
DOI: 
10.7727/wimjopen.2017.162
Pages: 
66–71
Synopsis: 
The study explored the relationship between facial acne severity, age of patients, body mass and physical activity indices. Acne severity has a significant relationship with age of patients but not body mass or physical activity indices.

Objective: To explore the relationship between severities of acne with age, body mass index (BMI) and physical activity index (PAI) of the patients.

Revised: 
October 15, 2018
Accepted: 
December 20, 2017
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A Retrospective Study of Skin Manifestations in Systemic Lupus Erythematosus and their association with Renal Involvement

Issue: 
DOI: 
10.7727/wimjopen.2018.101
Pages: 
61–5
Synopsis: 
This study explored the relationship between skin manifestations and renal disease in systemic lupus erythematosus (SLE). Patients with lupus erythematosus non-specific skin disease were more likely to have renal involvement.

Objective: To identify the types of skin disorders seen in systemic lupus erythematosus (SLE) and to establish the correlation, if any, between cutaneous manifestations, lupus erythematosus (LE) specificity and renal involvement.

Accepted: 
August 7, 2018
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Journal Sections: 

Clinical and Epidemiological Follow-up of Patients with Arthralgia Post Probable Chikungunya Referred to a Rheumatology Clinic at a Tertiary Hospital in Trinidad and Tobago T

Issue: 
DOI: 
10.7727/wimjopen.2018.026
Pages: 
56–60
Synopsis: 
This study described the arthralgia post chikungunya infection in patients referred to a rheumatology clinic at a tertiary hospital in Trinidad and Tobago. These patients are likely to be female and more than 45 years old. The joints most involved are the knees, shoulders, wrist and ankles in a symmetrical distribution; 77.3% of patients perceived that these symptoms negatively affected their daily activities.

Objective: To describe the arthralgia post Chikungunya (ChikV) infection in patients referred to a rheumatology clinic at a tertiary hospital in Trinidad. 

Methods: Patients referred for arthralgia and prior probable ChikV-infection were surveyed. Probable ChikV-infection was defined as a clinically compatible case as reported by the patient or the healthcare provider, absence of a more likely explanation and a positive ChikV specific enzyme-linked immunosorbent assay (ELISA) for immunoglobulin (Ig) G. 

Accepted: 
June 15, 2018
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Value of Balanced Fast Field Echo-assisted Three Dimensional Time-of-flight to Diagnose Intracranial Arterial Stenosis

Issue: 
DOI: 
10.7727/wimjopen.2017.197
Pages: 
52–5
Synopsis: 
The balanced fast field echo (BFFE) technique employs a fully-balanced gradient waveform along all three axes, which allows magnetization to reach a steady state, providing fluids with good signal-to-noise ratios (SNRs) and excellent tissue contrast. Balanced fast field echo can then be used as diagnostic pulse sequence for blood vessels or fluid-filled tissues.

Magnetic resonance angiography (MRA) is a non-invasive vascular imaging technique. It can resolve the 3D morphology and structure of the circle of Willis when used in conjunction with three dimensional time-of-flight (3D TOF) and maximum intensity projection (MIP) technology. However, slow blood flow or saturation effects will cause signal loss in 3D TOF, and affect the accuracy of diagnosis.

Accepted: 
August 18, 2018
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Descriptive Epidemiology of Haemophilia in Martinique

Issue: 
DOI: 
10.7727/wimjopen.2017.184
Pages: 
47–51
Synopsis: 
This study described for the first time the descriptive epidemiology of patients harbouring haemophilia in Martinique and the context of haemophilia care since the creation of the Martinique Treatment Centre.

Objective: Haemophilia is a congenital bleeding disorder characterized by partial or complete deficiency of a clotting factor VIII (FVIII) for Haemophilia A (HA), or factor IX (FIX) for Haemophilia B (HB). In this study, we describe the epidemiology of haemophilia in patients from Martinique, a French Caribbean Island with a population of predominantly Afro-Caribbean origin. This epidemiological study has never been described before, and the associated specific mutations for the corresponding genes were unknown. 

Accepted: 
December 18, 2017
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Outcome of Dengue in Hospitalized Jamaican Children

Issue: 
DOI: 
10.7727/wimjopen.2016.525
Pages: 
25-32
Synopsis: 
Before the emergence of Zika in 2016 and Chikungunya in 2014, there have been numerous Dengue outbreaks in the Caribbean. Despite this, there is a paucity of published studies on Dengue in children from this region. The potential for exponential spread of the Aedes aegypti dengue vector and its deleterious outcomes in children underlines the importance of this paper.

Background: Dengue fever is hyper-endemic in Jamaica with exponential rates of infection in successive outbreaks. The absence of local data and the potential for massive outbreaks in a country where a third of the population are children formed the basis for this study. 

Accepted: 
December 26, 2015
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Journal Sections: 

Acute Paralysis and Neuro-inflammation in Jamaican Children during Zika virus and Dengue Epidemics of 2016

Issue: 
DOI: 
10.7727/wimjopen.2016.526
Pages: 
12-7
Synopsis: 
This case series suggests a unique clinical pattern of neuro-inflammation in Jamaican adolescents occurring during the ZIKV epidemic and questions the role of the three circulating arbo-viruses in the pathogenesis.

Dengue, Chikungunya fever (CHIKV) and Zika virus (ZIKV) are all transmitted by the Aedes aegypti mosquito and are currently circulating in Jamaica. Jamaica has been experiencing a ZIKV epidemic since February 2016. At the University Hospital of the West Indies (UHWI), Kingston, Jamaica, a cluster of five cases of paralysis attributed to neuro-inflammation was noted amongst adolescents admitted to the Institution. Three were diagnosed with acute myelitis and one each with acute disseminated encephalomyelitis (ADEM) and Guillain-Barre Syndrome (GBS).

Accepted: 
October 24, 2016
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Journal Sections: 

Unravelling the Paediatric and Perinatal Zika Virus Epidemic through Population-based Research

Issue: 
DOI: 
10.7727/wimjopen.2016.454
Pages: 
1-4
Synopsis: 
Zika virus causes Guillain-Barre Syndrome and microcephaly. Clinical and laboratory diagnosis is complicated. Population-based research can elucidate ZIKV epidemiology, vertical transmission, fetal risks of maternal ZIKV infection and natural history of congenital and non-congenital ZIKV infection provided by the activities in “ZIKAction” research consortium, recently funded by the European Commission.

Zika virus (ZIKV) epidemic now involves 72 countries, worldwide. Transmission is multimodal through mosquito bites and blood and body fluids. Zika virus causes Guillain-Barre Syndrome and pregnancy complications including perinatal microcephaly. Diagnosis is complicated by subclinical infection in 80%, co-circulation with dengue and chikungunya fevers with similar presentations and cross-reactivity in serological tests. There is no cure, or preventive vaccine.

Accepted: 
August 23, 2016
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Journal Authors: 

An Utstein-style Investigation into the Association between Prognoses and the Conditions of Patients with Out-of-hospital Cardiac Arrest

Issue: 
DOI: 
10.7727/wimjopen.2017.070
Pages: 
12-6
Synopsis: 
At the time of the emergency call (119), the subsequent survival rate is high, particularly in conscious cases with chest pain/back pain/respiratory distress or in cases in which the caller cannot confirm respiratory arrest.

ABSTRACT

Accepted: 
February 13, 2017
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Journal Sections: 

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