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Ameliorative Effect of Zinc Oxide and Silver Nanoparticles on Antioxidant System in the Brain of Diabetic Rats

Journal Authors: 


Objective: The present study tests the ability of both zinc oxide (ZnONPs) and silver (SNPs) nanoparticles to ameliorate the oxidative stress resulted from diabetes in diabetic rats was tested in the present study.

Methods: Fifty male albino rats are randomly used; ten of them are served as a control and forty rats injected with single dose (100 mg/kg) of streptozotocin intraperitoneal. They were subdivided into, diabetic + ZnONPs, diabetic + SNPs and diabetic + insulin. The activities and mRNA expression levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GRD) were determined in brain tissues. Malondialdehyde (MDA), total antioxidant capacity (TAC), zinc (Zn) and silver (Ag) concentrations were estimated in the brain tissues of all rats.

Results: A significant increase in the activities and mRNA expression levels of SOD, CAT, GPx and GRD was shown. MDA levels were significantly decreased where there is a significant increase in the Zn, Ag and TAC in brain of ZnONPs and SNPs treated rats when compared with diabetic or diabetic + insulin and their control.

Conclusion: ZnONPs and SNPs can be used to ameliorate the oxidative stress in brain resulted from diabetes mellitus.   

12 Jun, 2015
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e-Published: 17 Aug, 2015


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