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Ameliorative Effect of Zinc Oxide and Silver Nanoparticles on Antioxidant System in the Brain of Diabetic Rats

Journal Authors: 
DOI: 
10.7727/wimj.2015.296

ABSTRACT

Objective: The present study tests the ability of both zinc oxide (ZnONPs) and silver (SNPs) nanoparticles to ameliorate the oxidative stress resulted from diabetes in diabetic rats was tested in the present study.

Methods: Fifty male albino rats are randomly used; ten of them are served as a control and forty rats injected with single dose (100 mg/kg) of streptozotocin intraperitoneal. They were subdivided into, diabetic + ZnONPs, diabetic + SNPs and diabetic + insulin. The activities and mRNA expression levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GRD) were determined in brain tissues. Malondialdehyde (MDA), total antioxidant capacity (TAC), zinc (Zn) and silver (Ag) concentrations were estimated in the brain tissues of all rats.

Results: A significant increase in the activities and mRNA expression levels of SOD, CAT, GPx and GRD was shown. MDA levels were significantly decreased where there is a significant increase in the Zn, Ag and TAC in brain of ZnONPs and SNPs treated rats when compared with diabetic or diabetic + insulin and their control.

Conclusion: ZnONPs and SNPs can be used to ameliorate the oxidative stress in brain resulted from diabetes mellitus.   

Accepted: 
12 Jun, 2015
PDF Attachment: 
e-Published: 17 Aug, 2015

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Manuscripts that are “Published at Acceptance” have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear prior to being copy edited or formatted in the style guide of this Journal. The contents of the manuscript may change before it is published in its final form. While accepted manuscripts are not yet assigned a volume, issue, or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. Manuscripts in this section will be removed once they have been assigned to a volume and issue, but will still retain the DOI and date of e-publication.

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