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Protective Effect of Montelukast Sodium in Acute Ethyl Alcohol-induced Hepatic Injury in Rats

DOI: 
10.7727/wimj.2015.431

ABSTRACT

Objective: Ethyl alcohol (EA) is a substance that is used commonly worldwide and known to have toxic effects on the liver. The aim of this study was to investigate the effect of montelukast sodium (MK) on acute hepatopathy induced by a single dose of EA in rats.

Methods: The study consisted of four groups each containing eight Wistar Albino male rats. The groups were classified as follows: Control group received distilled water; ethyl alcohol group received 6 g/kg ethyl alcohol diluted with distilled water orally by gavage; montelukast sodium group received 30 mg/kg montelukast sodium orally by gavage; ethyl alcohol+montelukast sodium group received, two hours after ethyl alcohol administration, 30 mg/kg montelukast sodium orally by gavage.  After 24 hours, all rats were sacrificed and blood and liver tissue samples were taken for biochemical and histopathological examination.

Results: The administration of EA caused a statistically significant increase in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels compared to the control group (220.50±66.90 and 92.38±5.90 versus 84.88±15.66 and 43.75±10.22). The administration of ethyl alcohol+montelukast sodium caused a statistically significant decrease in AST and ALT levels compared to the EA alone group.  Ethyl alcohol administered rat caused lesion in liver including congestions, hydropic degeneration and irregular shaped area caused coagulation necrosis. The histopathological changes seen in ethyl alcohol group were not detected in ethyl alcohol+montelukast sodium group.

Conclusion: Consequently, these data suggested that MK had beneficial effects in alleviating ethyl alcohol-induced hepatotoxicity.

Accepted: 
17 Nov, 2015
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e-Published: 04 Mar, 2016

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