G Turkcu

Protective Effects of Caffeic Acid Phenethyl Ester on Isoniazid and Rifampicin-induced Hepatic and Pancreatic Injury

Issue:

Vol 69, Issue 5: 2021

DOI:

10.7727/wimj.2015.561

Pages:

350-5

Synopsis:

This study investigated the protective effects of caffeic acid phenethyl ester (CAPE) against rifampicin-isoniazid-induced hepatic and pancreatictoxicity in terms of histopathological deterioration, oxidative stress (paraoxonase-1, total antioxidant status, total oxidant status) and biochemical parameters changes. The side effects of isoniazid and rifampicin treatment on hepatic and pancreatic tissues may be prevented with CAPE.

ABSTRACT

Objective: To investigate the protective effects of caffeic acid phenethyl ester (CAPE) against isoniazid (INH)- and rifampicin (RFP)-induced hepatic and pancreatic damage.

Received:

16 Nov, 2015

Accepted:

04 Jan, 2016

Published:

12 Nov, 2021

PDF Attachment:

wimj-iss5-2021_350_355.pdf

Journal Sections:

Original Articles

Keywords:

Caffeic acid phenethyl ester

Journal Authors:

e-Published: 30 Mar, 2016

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Protective Effect of Montelukast Sodium in Acute Ethyl Alcohol-induced Hepatic Injury in Rats

Issue:

Vol 69, Issue 5: 2021

DOI:

10.7727/wimj.2015.431

Pages:

345-9

Synopsis:

The aim of this study was to investigate the effect of montelukast sodium on acute hepatopathy induced by ethyl alcohol in rats. The liver tissue and biochemical parameters were assessed. Montelukast sodium administration had beneficial effects in alleviating ethyl-alcohol-induced hepatotoxicity.

ABSTRACT

Objective: Ethyl alcohol (EA) is a substance that is used commonly worldwide and known to have toxic effects on the liver. The aim of this study was to investigate the effect of montelukast sodium (MK) on acute hepatopathy induced by a single dose of EA in rats.

Received:

03 Aug, 2015

Accepted:

17 Nov, 2015

Published:

12 Nov, 2021

PDF Attachment:

wimj-iss5-2021_345_349.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 04 Mar, 2016

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Malignant Melanoma and Atypical Fibroxanthoma: An Unusual Collision Tumour

Issue:

Vol 69, Issue 9: 2023

DOI:

10.7727/wimj.2016.004

Pages:

652-4

ABSTRACT

Two different neoplasms in the same biopsy material, called collision tumour, were studied. These tumours are rarely seen in the skin. We report the case of a 79-year-old female with a collision tumour composed of amelanotic malignant melanoma and atypical fibroxanthoma of the face. The histological and immunopathological features observed are discussed.

Received:

05 Jan, 2016

Accepted:

11 Jan, 2016

Published:

25 Jan, 2023

PDF Attachment:

wimj-iss9-2023_652_654.pdf

Journal Sections:

Case Reports

Keywords:

Atypical fibroxanthoma

Journal Authors:

e-Published: 23 Feb, 2016

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Effect of L-ornithine L-aspartate on Liver Injury Due to Acute Ethyl Alcohol Intoxication in Rats

Issue:

Vol 64, Issue 3: June (2015)

DOI:

10.7727/wimj.2014.325

Pages:

189–94

Synopsis:

Acute ethyl alcohol intoxication and related acute alcoholic hepatitis pose serious problems to emergency departments. Reactive oxygen radicals play an important role in ethyl alcohol-induced hepatotoxicity. L-ornithine L-aspartate significantly reduced hepatic injury and decreased oxidative stress causing liver injury.

ABSTRACT

Objective: Ethyl alcohol is a substance that is widely used worldwide and known to exert toxic effects on liver. In this study, we aimed to examine the effect of L-ornithine L-aspartate (LOLA) on the toxicity of a single dose of ethyl alcohol in rats.

Received:

19 Nov, 2014

Accepted:

25 Mar, 2015

PDF Attachment:

wimjjun2015_189_194.pdf

Journal Sections:

Original Articles

Keywords:

Ethyl alcohol

total oxidant status

oxidative stress index