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A Ozhasenekler

Protective Effect of Montelukast Sodium in Acute Ethyl Alcohol-induced Hepatic Injury in Rats

DOI: 
10.7727/wimj.2015.431
Synopsis: 
The aim of this study was to investigate the effect of montelukast sodium on acute hepatopathy induced by ethyl alcohol in rats. The liver tissue, and biochemical parameters were assessed. Montelukast sodium administration had beneficial effects in alleviating ethyl alcohol-induced hepatotoxicity.

ABSTRACT

Objective: Ethyl alcohol (EA) is a substance that is used commonly worldwide and known to have toxic effects on the liver. The aim of this study was to investigate the effect of montelukast sodium (MK) on acute hepatopathy induced by a single dose of EA in rats.

Accepted: 
17 Nov, 2015
PDF Attachment: 
Journal Sections: 
e-Published: 04 Mar, 2016

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Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Effect of L-ornithine L-aspartate on Liver Injury Due to Acute Ethyl Alcohol Intoxication in Rats

Issue: 
DOI: 
10.7727/wimj.2014.325
Pages: 
189–94
Synopsis: 
Acute ethyl alcohol intoxication and related acute alcoholic hepatitis pose serious problems to emergency departments. Reactive oxygen radicals play an important role in ethyl alcohol-induced hepatotoxicity. L-ornithine L-aspartate significantly reduced hepatic injury and decreased oxidative stress causing liver injury.

ABSTRACT

Objective: Ethyl alcohol is a substance that is widely used worldwide and known to exert toxic effects on liver. In this study, we aimed to examine the effect of L-ornithine L-aspartate (LOLA) on the toxicity of a single dose of ethyl alcohol in rats.

Accepted: 
25 Mar, 2015
PDF Attachment: 
Journal Sections: 
e-Published: 23 Apr, 2015
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