A Ozhasenekler

Protective Effect of Montelukast Sodium in Acute Ethyl Alcohol-induced Hepatic Injury in Rats

Issue:

Vol 69, Issue 5: 2021

DOI:

10.7727/wimj.2015.431

Pages:

345-9

Synopsis:

The aim of this study was to investigate the effect of montelukast sodium on acute hepatopathy induced by ethyl alcohol in rats. The liver tissue and biochemical parameters were assessed. Montelukast sodium administration had beneficial effects in alleviating ethyl-alcohol-induced hepatotoxicity.

ABSTRACT

Objective: Ethyl alcohol (EA) is a substance that is used commonly worldwide and known to have toxic effects on the liver. The aim of this study was to investigate the effect of montelukast sodium (MK) on acute hepatopathy induced by a single dose of EA in rats.

Received:

03 Aug, 2015

Accepted:

17 Nov, 2015

Published:

12 Nov, 2021

PDF Attachment:

wimj-iss5-2021_345_349.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 04 Mar, 2016

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Effect of L-ornithine L-aspartate on Liver Injury Due to Acute Ethyl Alcohol Intoxication in Rats

Issue:

Vol 64, Issue 3: June (2015)

DOI:

10.7727/wimj.2014.325

Pages:

189–94

Synopsis:

Acute ethyl alcohol intoxication and related acute alcoholic hepatitis pose serious problems to emergency departments. Reactive oxygen radicals play an important role in ethyl alcohol-induced hepatotoxicity. L-ornithine L-aspartate significantly reduced hepatic injury and decreased oxidative stress causing liver injury.

ABSTRACT

Objective: Ethyl alcohol is a substance that is widely used worldwide and known to exert toxic effects on liver. In this study, we aimed to examine the effect of L-ornithine L-aspartate (LOLA) on the toxicity of a single dose of ethyl alcohol in rats.

Received:

19 Nov, 2014

Accepted:

25 Mar, 2015

PDF Attachment:

wimjjun2015_189_194.pdf

Journal Sections:

Original Articles

Keywords:

Ethyl alcohol

total oxidant status

oxidative stress index