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A Study of the Association between Diabetes Mellitus and Chronic Hepatitis B Virus Infection



Background: Hepatitis B Virus (HBV) infection and diabetes mellitus are major health problems associated with significant morbidity and mortality. Published literature suggests an association of diabetes mellitus with liver diseases. However, the role of HBV infection in diabetes etiology is still controversial. The present study was performed to explore the veracity of this enigmatic association among Pakistani subjects.

Methodology: The blood samples and clinical information were collected from chronic HBV positive patients (n=120), and age and gender matched healthy control subjects (n=120). HBV positive patients were also subdivided into two groups i.e. with and without liver cirrhosis for the prevalence of diabetes.

Results: The study revealed that there were number of significant differences in these two groups in the biochemical parameters among HBV positive and control groups. The association study of diabetes in these two groups indicated no correlation between diabetes and HBV. Since there were a relatively large number of HBV positive patients with liver cirrhosis i.e. 32.5%, so a comparison of biochemical parameters was also carried out to understand the extent of liver damage and its association with diabetes. During comparison of HBV patients with and without cirrhosis for the prevalence of diabetes, no etiologic association was found.

Conclusion: This study concludes that there was no correlation between HBV infection and diabetes despite significantly different biochemical parameters among HBV infected and control subjects.

25 Nov, 2015
e-Published: 30 Mar, 2016


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