ABSTRACT
Cannabinoids isolated from cannabis spp. have been the subject of much research over at least three decades. Extensive research has been conducted on the mode of action of this group of compounds which elicits a variety of therapeutic activity. Research has revealed that phytocannabinoids have similar activity as endocannabinoids {ElSohly, 2007 #10}and can act as ligands in the endocannabinoid system. The endocannabinoid system is a neuromodulatory system that regulates some important bodily functions. With the existing preclinical and clinical trials and the activity of cannabis derived analgesics, cannabinoids shows great potential in curtailing the concerns of traditional pain modulators. This review article highlights research on cannabinoids as an analgesic in the management of several pain states such as neuropathy, migraine, arthritis, and sickle cell disease.
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