Synopsis:
The study demonstrated that a shortened conditioning period of 18 minutes in the conditioned place preference paradigm could induce significant delta-9-tetrahydrocannabinol (∆9-THC) reward at low doses, supporting the addictive potential of the psychoactive agent of marijuana. This is the first report of significant reward at a dose of 0.05 mg/kg of ∆9-THC in an animal model of addiction.