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Sickle Cell Disease

Reduced Frequency of Bone Pain Crises in Patients with Sickle Cell Disease Given an Angiotensin-converting Enzyme Inhibitor

Issue: 
DOI: 
10.7727/wimj.2018.137
Pages: 
24-8
Synopsis: 
Bone pain is a chronic debilitating feature of sickle cell disease requiring opioid analgesia with a risk of addiction. Angiotensin-converting enzyme inhibition whose benefit was previously reported in the West Indies was tried in a Nigerian cohort and was found to be encouraging.

ABSTRACT

Objective: To determine if sickle cell disease (SCD) bone pain crisis is mitigated by use of an angiotensin-converting enzyme inhibitor (ACEI), following a case report of ACEIs preventing bone pain crisis.

Accepted: 
26 Dec, 2018
PDF Attachment: 
Journal Sections: 
e-Published: 25 Mar, 2019

Characterization of Neuropathic Pain in Sickle Cell Disease

Issue: 
DOI: 
10.7727/wimj.2017.164
Pages: 
503–9
Synopsis: 
This study sought to identify the amount of nociceptive, affective and neuropathic pain components in sickle cell disease (SCD) in Grenada, West Indies. Characterization of pain in SCD will contribute to increased awareness and promote the development of adequate and effective pain management guidelines.

ABSTRACT

Accepted: 
09 Oct, 2017
PDF Attachment: 
Journal Sections: 
e-Published: 05 Oct, 2017

Epidemiology of the Sickle Cell Disease in Grenada: A Comparison with Haiti, Jamaica and United States of America

Issue: 
DOI: 
10.7727/wimj.2017.129
Pages: 
491–6
Synopsis: 
This study estimates the average prevalence, case-fatality rate and cause-specific mortality rate of SCD in Grenada, West Indies, and compares the epidemiology to that in the United States of America and elsewhere in the Caribbean.

ABSTRACT

Objective: Sickle cell disease (SCD) is a multifaceted, chronic disease severely affecting the quality of life of patients and their families. In addition, it is becoming a costly public health concern. In comparing the epidemiology, management and outcome of SCD in the United States of America and the Caribbean, this article aimed to promote awareness of SCD and the need for adequate treatment.

Accepted: 
12 Jun, 2017
PDF Attachment: 
Journal Sections: 
e-Published: 11 Jul, 2017

A Note on the Prevalence of Impaternity in Jamaica

Issue: 
DOI: 
10.7727/wimj.2016.546
Pages: 
521

 The Editor,

 Sir,

Genetics studies often depend on the certainty of correct genotypes in both parents.  In Jamaica, it is common knowledge that some fathers may not be the true biological father but the prevalence of impaternity is not published because of the difficulties and expense of determining the biological fathers by DNA studies.

Accepted: 
03 Jul, 2017
PDF Attachment: 
Journal Sections: 
Journal Authors: 
e-Published: 03 Jul, 2017

Jamaica and Research in Sickle Cell Disease

Issue: 
DOI: 
10.7727/wimj.2016.547
Pages: 
457–68
Synopsis: 
Many developments have occurred in sickle cell disease and care over the last 50 years in Jamaica. The clinic population grew from 50–60 in the mid-1960s to 5500 in late 1999. During this period, the number of staff serving sickle cell patients increased from 2 to 28, comprising physicians, paediatricians, nurses, laboratory technologists, social workers, computer staff and statisticians. The physical facilities have improved greatly, and data management has evolved from the type written long narrow paper strips in the late 1960s to sophisticated electronic patient management systems. The many physical resources and the superb opportunities of an ‘island laboratory’ have pro-vided a unique basis for clinical research into the disease.

ABSTRACT

Accepted: 
03 Jul, 2017
PDF Attachment: 
Journal Sections: 
Journal Authors: 
e-Published: 03 Jul, 2017

Perioperative Management of Paediatric Patients with Sickle Cell Disease

Issue: 
DOI: 
10.7727/wimj.2017.135
Pages: 
469–77
Synopsis: 
Perioperative care of children with sickle cell disease is associated with adverse outcomes. In concert with haematology consultants, surgeons, anaesthesiologists and intensivists, there are optimized perioperative outcomes with meticulous preoperative preparation, intra-operative management and postoperative care.

ABSTRACT

Accepted: 
03 Jul, 2017
PDF Attachment: 
Journal Sections: 
e-Published: 03 Jul, 2017

Cannabinoids and Cannabis Based Medicines in the Treatment of Chronic Pain: A Review

DOI: 
10.7727/wimj.2016.513
Synopsis: 
Anecdotal and traditional use has long proclaimed the use of cannabis in the management of a number of pain conditions. The article outlines the use of cannabinoids and cannabis based medicines in the treatment of chronic pain.

ABSTRACT

Accepted: 
11 Jan, 2017
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Journal Sections: 
Journal Authors: 
e-Published: 25 Jan, 2017

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

The Effect of Hydroxyurea therapy on Adverse Clinical Events and Haematological Indices in Paediatric Patients with Sickle Cell Anaemia

Issue: 
DOI: 
10.7727/wimj.2015.538
Pages: 
80–85
Synopsis: 
The vast majority of available evidence on the efficacy, effectiveness and safety of hydroxyurea in childhood sickle cell anaemia (SCA) is mostly from high-income countries. The conclusions drawn from this study would be useful in guiding hydroxyurea use in other less developed countries with limited resources.

ABSTRACT

Objective: The aim of this study was to determine the effect of hydroxyurea on adverse clinical events and haematological indices in paediatric patients with sickle cell anaemia.

Method: This study compared the same cohort of patients before and after hydroxyurea therapy, monitoring the rate of adverse events, pre- and post-treatment and haematological indices.

Accepted: 
17 Nov, 2015
PDF Attachment: 
Journal Sections: 
e-Published: 31 Mar, 2016

Prevalence of Sickle Cell Disease among Newborns in St Vincent and the Grenadines: A Retrospective Study

Issue: 
DOI: 
10.7727/wimj.2015.593
Pages: 
486–90
Synopsis: 
This is a retrospective study to determine the prevalence of sickle cell disease among lives births in St Vincent and the Grenadines. The results of this study indicate a birth prevalence that is similar to the published data from the other Caribbean Islands.

ABSTRACT

Objective: In the United States of America (USA), sickle cell disease (SCD) occurs in 1:375 African-American births. However, published data from the Caribbean have revealed higher numbers for some Caribbean islands. St Vincent and the Grenadines (SVG) is a multi-island nation in the Caribbean, and there are currently no data on the incidence or prevalence of the disease in this population. The objective of this study was to obtain birth prevalence estimates for SCD in SVG.

Accepted: 
07 Jan, 2016
PDF Attachment: 
Journal Sections: 
e-Published: 08 Mar, 2016

Newborn Screening for Sickle Cell Disease: Jamaican Experience

Issue: 
DOI: 
10.7727/wimj.2015.492
Pages: 
18–26
Synopsis: 
The history and evolution of laboratory technology for newborn screening for sickle cell disease is reviewed with particular reference to Jamaica. The procedures and results of screening 54 566 newborns from southern and western Jamaica are presented.

ABSTRACT

Objectives:  To review the history of newborn screening for sickle cell disease with especial reference to Jamaica.

Methods: A summary of the history, the development of associated laboratory technology and the implementation of newborn screening for sickle cell disease in Jamaica.

Accepted: 
22 Sep, 2015
PDF Attachment: 
Journal Sections: 
e-Published: 22 Sep, 2015

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