ABSTRACT
Objective: To investigate the antihyperglycemic, antihyperlipidemic and pancreatic beta cells regeneration potentials of Onosma hispidum (ratanjot) root extracts in alloxan-induced diabetic rabbits.
Methods: Among treatment groups, group 1 was vehicle with normal healthy rabbits as negative control. Second group had diabetic control (diabetic rabbits as positive control) rabbits. Diabetic rabbits treated with 100 mg/kg body weight methanolic extract of O. hispidum and 100mg/kg body weight n-haxane extract of O. hispidum were third and fourth groups. The groups treated with O. hispidum extracts were also compared against glibenclamide (oral antidiabetic agent) as a standard. Blood glucose, triacylgylcerides, cholesterol, HDL-C and LDL-C were measured by standard methods.
Results: Diabetic group treated with methanol extract showed significant reduction in blood glucose levels (29.94%; p < 0.05) and TAG (40.08%; p < 0.05) as compared to treated group and controls. However, O. hispidum treatment did not normalize these parameters in diabetic animals as compared to synthetic drug. Histopathological examination showed trivial pancreatic beta cells restoration activity.
Conclusions: O. hispidum roots have the potential to lower blood glucose and lipid profile in diabetic condition. Extensive natural explorations are encouraged in the quest for dietary adjuncts for diabetes management
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