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Alloxan

Antidiabetic Potential of Onosma hispidum Roots

DOI: 
10.7727/wimj.2016.436
Synopsis: 
In present study, antidiabetic potential of Onosma hispidum roots were assessed in diabetic animal models. O hispidum roots exhibited antihyperglycemic and antihyperlipidemic effects. In addition, histopathological investigation revealed pancreatic beta cells regeneration activity by plant roots.

ABSTRACT

Objective: To investigate the antihyperglycemic, antihyperlipidemic and pancreatic beta cells regeneration potentials of Onosma hispidum (ratanjot) root extracts in alloxan-induced diabetic rabbits.

Accepted: 
13 Feb, 2017
PDF Attachment: 
Journal Sections: 
Journal Authors: 
e-Published: 02 Mar, 2017

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

The Effects on Offspring of Diabetes Mellitus Induced by Chemical Agents in Rats with Advanced Pregnancy

Issue: 
DOI: 
10.7727/wimj.2015.587
Pages: 
56-9
Synopsis: 
Diabetes is the most important cause of perinatal mortality, and a four- to eight-fold greater malformation rate is observed among babies of diabetic mothers than among the general population. Cardiac anomalies and central nervous system anomalies are the most common anomalies observed in babies of diabetic mothers.

ABSTRACT

Background: Gestational diabetes mellitus is an increasingly frequent metabolic disorder that is important for both baby and mother. New studies on the development and treatment of the disease are required.

Objective: To investigate the effects on offspring’s survival and the biochemical values of diabetes mellitus, induced by different doses of two chemical agents among 35 rats with advanced pregnancy.

Accepted: 
07 Dec, 2015
PDF Attachment: 
Journal Sections: 
Journal Authors: 
e-Published: 30 Mar, 2016
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