ABSTRACT
Objective: To evaluate the effects of continuous positive airway pressure (CPAP) on serum cystatin C and leptin concentration levels in patients with obstructive sleep apnea hypopnea syndrome (OSAHS).
Methods: 69 OSAHS patients treated with CPAP were selected as the experimental group and 69 healthy subjects who received physical examinations in the hospital were selected as the control group. The basal metabolic levels in both groups, before and after treatment, were measured, compared and analyzed statistically.
Results: Before treatment, BMI, respiratory disturbance index and micro-arousal index of the experimental group were significantly higher than those of the control group. The lowest SaO2 was significantly lower than that in the control group (p < 0.05). After treatment, the basal metabolic indicators in the experimental group significantly improved (p < 0.05). Prior to treatment, the levels of serum cystatin C and leptin in the experimental group were significantly higher than those in the control group (p < 0.05). Following CPAP treatment, the levels of cystatin C and leptin in the experimental group fell significantly (p < 0.05) and were close to those in the control group.
Conclusions: Continuous positive airway pressure therapy can help improve basal metabolic levels in OSAHS patients. It also has a very positive effect in reducing serum cystatin C and leptin levels. CPAP can modulate OSAHS disease progression significantly.
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