Obstructive sleep apnea hypopnea syndrome (OSAHS) is a sleep-related respiratory disorder that increases the risk of several other diseases. We evaluated the mode of action of continuous positive airway pressure (CPAP), which is the treatment of choice, in OSAHS therapy. The results of this study reveal that CPAP acts by reducing the levels of cystatin C and leptin in the serum which are involved in raising the basal metabolic rate in OSAHS.

Leptin and Endothelin (ET) as important endogenous factors interact with each other which may contribute to a better understanding their role in diabetic pathogenesis. We aimed to evaluate the relationship between Leptin and ET by investigating the influence of BQ-123, an ET-A receptor (ETAR) antagonist, on Leptin levels in rats with diabetes induced by Streptozotocin (STZ). In this study, 24 male Wistar-albino rats were divided into three groups; Control, STZ, STZ + BQ-123 relatively reduced oxidative stress and Leptin levels. ETaR ANTAGONIST bq-123 has positive impacts depending on the dosage in the diabetic rats.