Synopsis:
Leptin and Endothelin (ET) as important endogenous factors interact with each other which may contribute to a better understanding their role in diabetic pathogenesis. We aimed to evaluate the relationship between Leptin and ET by investigating the influence of BQ-123, an ET-A receptor (ETAR) antagonist, on Leptin levels in rats with diabetes induced by Streptozotocin (STZ). In this study, 24 male Wistar-albino rats were divided into three groups; Control, STZ, STZ + BQ-123 relatively reduced oxidative stress and Leptin levels. ETaR ANTAGONIST bq-123 has positive impacts depending on the dosage in the diabetic rats.