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Leptin

Effects of Continuous Positive Airway Pressure Ventilation on Serum Cystatin C and Leptin Concentration Levels in Patients with Obstructive Sleep Apnea Hypopnea Syndrome

DOI: 
10.7727/wimj.2017.138
Pages: 
Synopsis: 
Obstructive sleep apnea hypopnea syndrome (OSAHS) is a sleep-related respiratory disorder that increases the risk of several other diseases. We evaluated the mode of action of continuous positive airway pressure (CPAP), which is the treatment of choice, in OSAHS therapy. The results of this study reveal that CPAP acts by reducing the levels of cystatin C and leptin in the serum which are involved in raising the basal metabolic rate in OSAHS.

ABSTRACT

Objective: To evaluate the effects of continuous positive airway pressure (CPAP) on serum cystatin C and leptin concentration levels in patients with obstructive sleep apnea hypopnea syndrome (OSAHS).

Accepted: 
12 Dec, 2017
Journal Sections: 
Journal Authors: 
e-Published: 23 Jan, 2018

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Effects of Endothelin-A Receptor Antagonist BQ-123 on Plasma Leptin Levels Streptozotocin Induced Diabetic Rats

DOI: 
10.7727/wimj.2016.106
Synopsis: 
Leptin and Endothelin (ET) as important endogenous factors interact with each other which may contribute to a better understanding their role in diabetic pathogenesis. We aimed to evaluate the relationship between Leptin and ET by investigating the influence of BQ-123, an ET-A receptor (ETAR) antagonist, on Leptin levels in rats with diabetes induced by Streptozotocin (STZ). In this study, 24 male Wistar-albino rats were divided into three groups; Control, STZ, STZ + BQ-123 relatively reduced oxidative stress and Leptin levels. ETaR ANTAGONIST bq-123 has positive impacts depending on the dosage in the diabetic rats.

ABSTRACT

 

Objectives: Leptin and Endothelin (ET) as important endogenous factors interact with each other which may contribute to a better understanding their role in diabetic pathogenesis.

We aimed to evaluate the relationship between Leptin and ET by investigating the influence of BQ-123, an ET-A receptor (ETAR) antagonist, on Leptin levels in rats with diabetes induced by Streptozotocin (STZ).

Accepted: 
25 May, 2016
PDF Attachment: 
Journal Sections: 
e-Published: 07 Jul, 2016

Pre-published Manuscript

This manuscript has been assigned to a volume and issue but has not yet been published. It is either being edited, typeset or is in the proof stage of publication.
In the pre-published stage, this manuscript may contain statements, opinions, and information that have errors in facts, figures, or interpretation. Any final changes in this manuscript will be made at the time of publication and will be reflected in the final electronic version of the issue. The editors and authors and their respective employees are not responsible or liable for the use of any such inaccurate or misleading data, opinion or information contained in the articles in this section.

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