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Rapamycin Improves Vascular Remodelling in a Controlled Rat Model of Monocrotaline-induced Pulmonary Hypertension

We evaluated the effect of rapamycin on pulmonary arterial hypertension. Rapamycin provided improvements in exercise capacity, right ventricular systolic pressure and hypertrophy, but those were not significant. There were significant recoveries in pulmonary artery muscular layer thickness and in the medium lifespan of rats.


Objective: Pulmonary arterial hypertension (PAH) is a serious disease characterized by progressive elevation of pulmonary arterial resistance, leading to right ventricular failure and death. We aimed to evaluate the effect of rapamycin (RAPA), a potent cell-cycle inhibitor, on exercise capacity, right ventricular hypertrophy, and pulmonary vascular remodeling.

18 May, 2015
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e-Published: 13 Aug, 2015


Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

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