A Sengul

Rapamycin Improves Vascular Remodelling in a Controlled Rat Model of Monocrotaline-Induced Pulmonary Hypertension

Issue:

Vol 69, Issue 9: 2023

DOI:

10.7727/wimj.2015.222

Pages:

638-44

Synopsis:

We evaluated the effect of rapamycin on pulmonary arterial hypertension. Rapamycin provided improvements in exercise capacity, right ventricular systolic pressure and hypertrophy, but those were not significant. There were significant recoveries in the pulmonary artery muscular layer thickness and in the median life span of rats.

ABSTRACT

Background: Pulmonary arterial hypertension (PAH) is a serious disease characterized by the progressive elevation of the pulmonary arterial resistance, leading to the right ventricular failure and death. Objective: To evaluate the effect of rapamycin (RAPA), a potent cell-cycle inhibitor, on exercise capacity, right ventricular hypertrophy and pulmonary vascular remodelling on rats.

Received:

04 May, 2015

Accepted:

18 May, 2015

Published:

25 Jan, 2023

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