Synopsis:
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease and advanced fibrosis is the most important predictor of mortality in NAFLD. In this study, homeostasis model of insulin resistance (HOMA-IR) and serum immunoglobulin (Ig) A levels are found as the independent predictors of hepatic fibrosis. Early estimation of fibrosis in NAFLD patients by using clinical parameters such as HOMA-IR and serum IgA that can be easily assessed during daily routine can lead to a strategy to choose the most appropriate candidate for liver biopsy and can increase the yield and decrease unnecessary biopsies with associated costs and morbidity.