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Fibrosis

Practical Predictors of Fibrosis in Non-alcoholic Fatty Liver Disease: Immunoglobulin-A and HOMA-IR

DOI: 
10.7727/wimj.2018.013
Synopsis: 
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease and advanced fibrosis is the most important predictor of mortality in NAFLD. In this study, homeostasis model of insulin resistance (HOMA-IR) and serum immunoglobulin (Ig) A levels are found as the independent predictors of hepatic fibrosis. Early estimation of fibrosis in NAFLD patients by using clinical parameters such as HOMA-IR and serum IgA that can be easily assessed during daily routine can lead to a strategy to choose the most appropriate candidate for liver biopsy and can increase the yield and decrease unnecessary biopsies with associated costs and morbidity.

ABSTRACT

Objective: Elevated immunoglobulin (Ig)-A levels and its relationship with fibrosis in alcoholic liver disease (ALD) were known. Non-alcoholic fatty liver disease (NAFLD) shows similar histology and pathophysiology with ALD. The potential relationship of serum Ig (IgA, IgG, and IgM) levels and other routinely used biochemical tests with the histological stage of liver damage in biopsy-proven NAFLD patients was investigated here.

Accepted: 
08 Aug, 2018
PDF Attachment: 
Journal Sections: 
e-Published: 14 Feb, 2019

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Association between Mannose-Binding Lectin 2 Gene Polymorphism and Liver Fibrosis in Patients with Chronic Viral Hepatitis

DOI: 
10.7727/wimj.2016.155
Synopsis: 
MBL2 Gene Polymorphism were investigated in patients with viral Hepatitis B and C. No significant differences in allele frequencies for any polymorphism were observed between patients and controls.

ABSTRACT

Objective: Mannose-Binding Lectin (MBL) has become a popular molecule in investigations on basic and clinical Gastroenterology and contributed to new approaches to the understanding of infectious and immune diseases associated with intestine and liver. The aim of the present study was to investigate the association between codon 54 polymorphisms in MBL2 gene coding MBL and predisposition to fibrosis in patients with viral Hepatitis B and C.

Accepted: 
25 May, 2016
PDF Attachment: 
Journal Sections: 
e-Published: 14 Jul, 2016

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

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