AN Yurtman

Activity of Amikacin, Ertapenem, Ciprofloxacin and Levofloxacin alone and in Combination against Resistant Nosocomial Pathogens by Time-Kill

Issue:

Vol 57, issue 2 (2008)

Pages:

106–11

Synopsis:

The purpose of this study was to determine the synergistic activity of amikacin, ertapenem and fluoroquinolones combinations against resistant nosocomial pathogens. The antibiotic combinations showed additive or synergistic activity against many of the Gramnegative pathogens.

ABSTRACT

Objective: The purpose of this study was to determine the synergistic activity of amikacin/ertapenem, fluoroquinolones (ciprofloxacin and levofloxacin)/ertapenem and amikacin/fluoroquinolones combinations against resistant nosocomial pathogens.

Methods: Time-kill studies were performed over 24 hours using an inoculum of 5 x 106 – 1 x 107 cfu/mL. Antibiotics were tested at the 1 x MIC and 4 x MIC concentrations.

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