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∆9-THC

Dosage and Conditioning Period Determine Reward or Aversion to Cannabis-induced Conditioned Place Preference in Sprague-Dawley Rats

DOI: 
10.7727/wimj.2017.185
Synopsis: 
The study demonstrated that a shortened conditioning period of 18 minutes in the conditioned place preference (CPP) paradigm can induce significant ∆9-THC reward at low doses, supporting the addictive potential of the psychoactive agent of marijuana. This is the first report of significant reward at a dose of 0.05 mg/kg ∆9-THC in an animal model of addiction.

  ABSTRACT                                                                                                                                     

Accepted: 
23 Oct, 2017
Journal Sections: 
Journal Authors: 
e-Published: 26 Oct, 2017

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