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LE Young

Dosage and Conditioning Period Determine Reward or Aversion to Cannabis-induced Conditioned Place Preference in Sprague-Dawley Rats

Issue: 
Vol 66, Issue 5: 2017 (Special Issue on Cannabis)
DOI: 
10.7727/wimj.2017.185
Pages: 
523-8
Synopsis: 
The study demonstrated that a shortened conditioning period of 18 minutes in the conditioned place preference paradigm could induce significant delta-9-tetrahydrocannabinol (∆9-THC) reward at low doses, supporting the addictive potential of the psychoactive agent of marijuana. This is the first report of significant reward at a dose of 0.05 mg/kg of ∆9-THC in an animal model of addiction.

ABSTRACT

Objective: To assess the addictive potential of cannabis by investigating the motivational responses to low doses of delta-9-tetrahydrocannabinol (Δ9-THC) and a marijuana tea extract (MTE), and to determine if the length of the conditioning period in the conditioned place preference (CPP) paradigm influences reward or aversion to these cannabinoid preparations.

Received: 
14 Sep, 2017
Accepted: 
23 Oct, 2017
Published: 
29 Dec, 2017
PDF Attachment: 
PDF icon wimj-iss5-2017_523_528.pdf
Journal Sections: 
Original Articles
Keywords: 
addiction
aversion
Cannabis
conditioned place preference
delta-9-tetrahydrocannabinol
Marijuana
motivation
reward
Journal Authors: 
LE Young
KP Chin-Quee
e-Published: 19 Dec, 2017

Dosage and Conditioning Period Determine Reward or Aversion to Cannabis-induced Conditioned Place Preference in Sprague-Dawley Rats

Synopsis: 
The study demonstrated that a shortened conditioning period of 18 minutes in the conditioned place preference paradigm could induce significant delta-9-tetrahydrocannabinol (∆9-THC) reward at low doses, supporting the addictive potential of the psychoactive agent of marijuana. This is the first report of significant reward at a dose of 0.05 mg/kg of ∆9-THC in an animal model of addiction.
Journal Sections: 
Original Articles
Journal Authors: 
LE Young
KP Chin-Quee
e-Published: 19 Dec, 2017

Pre-published Manuscript

This manuscript has been assigned to a volume and issue but has not yet been published. It is either being edited, typeset or is in the proof stage of publication.
In the pre-published stage, this manuscript may contain statements, opinions, and information that have errors in facts, figures, or interpretation. Any final changes in this manuscript will be made at the time of publication and will be reflected in the final electronic version of the issue. The editors and authors and their respective employees are not responsible or liable for the use of any such inaccurate or misleading data, opinion or information contained in the articles in this section.

Dosage and Conditioning Period Determine Reward or Aversion to Cannabis-induced Conditioned Place Preference in Sprague-Dawley Rats

DOI: 
10.7727/wimj.2017.185
Synopsis: 
The study demonstrated that a shortened conditioning period of 18 minutes in the conditioned place preference (CPP) paradigm can induce significant ∆9-THC reward at low doses, supporting the addictive potential of the psychoactive agent of marijuana. This is the first report of significant reward at a dose of 0.05 mg/kg ∆9-THC in an animal model of addiction.

  ABSTRACT                                                                                                                                     

Received: 
14 Sep, 2017
Accepted: 
23 Oct, 2017
Journal Sections: 
Original Articles
Keywords: 
∆9-THC
addiction
aversion
Cannabis
conditioned place reference
Marijuana
motivation
reward
Journal Authors: 
LE Young
KP Chin-Quee
e-Published: 26 Oct, 2017

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

An Extract of Neem Leaves Reduces Anxiety without Causing Motor Side Effects in an Experimental Model

Issue: 
Vol 59, issue 3 (2010)
Pages: 
245–8
Synopsis: 
Anxiety levels were assessed after treatment with either a steroidal extract of neem leaves or diazepam. An animal model of anxiety, the elevated X maze, provided reliable evidence of anxiolysis without motor deficit in neem treated rats.

ABSTRACT

PDF Attachment: 
PDF icon dr_thaxter.qxd_.pdf
Journal Sections: 
Original Articles
Keywords: 
Anxiety
Azadirachta indica
neem
X maze
Journal Authors: 
KA Thaxter
LE Young
RE Young
O Parshad
J Addae
e-Published: 07 Oct, 2013
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West Indian Medical Journal

Faculty of Medical Sciences,
The University of the West Indies,
Mona, Kingston 7
Tel: (876) 927-1214
Fax: (876) 927-1846
wimj@uwimona.edu.jm
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