Antinociception

Potassium Channel Openers Exhibit Cross-tolerance with Morphine in Two Experimental Models of Pain

Issue:

Vol 59, issue 5 (2010)

Pages:

473–8

Synopsis:

The study suggests that both morphine and potassium channel openers are cross-tolerant, which was assessed using formalin and tail-flick tests. However, such interaction occurs at the level of potassium channels rather than at the level of receptors.

ABSTRACT

Objective: The study was performed to assess the effect of potassium channel openers on morphine tolerance and vice-versa.

Methods: Swiss albino mice of either gender weighing between 25−30 g were used for the study. The study assesses the effect of potassium channel openers (cromakalim, diazoxide and minoxidil) on morphine tolerance and vice-versa, using formalin and tail-flick tests.

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