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Pharmacological Evaluation of Marginally Designed New Profen Analogues

This study was conducted for the pharmacological evaluation of some novel analogues of naproxen, flurbiprofen and ibuprofen, well established COX inhibitors, with the goal of identifying a COX inhibitor(s) with optimized potency and efficacy. The synthesized and characterized analogues were tested for their acute toxicity, anti-inflammatory, analgesic and antipyretic activities based on the reported bioassay models. Molecular docking analysis was also performed to predict ligand: protein interactions. The synthesized analogues have highly significant pharmacological activities and have the potential to be further explored as new drug molecules. 


13 Feb, 2017
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e-Published: 02 Mar, 2017


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