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COX

Pharmacological Evaluation of Marginally Designed New Profen Analogues

DOI: 
10.7727/wimj.2016.400
Synopsis: 
This study was conducted for the pharmacological evaluation of some novel analogues of naproxen, flurbiprofen and ibuprofen, well established COX inhibitors, with the goal of identifying a COX inhibitor(s) with optimized potency and efficacy. The synthesized and characterized analogues were tested for their acute toxicity, anti-inflammatory, analgesic and antipyretic activities based on the reported bioassay models. Molecular docking analysis was also performed to predict ligand: protein interactions. The synthesized analogues have highly significant pharmacological activities and have the potential to be further explored as new drug molecules. 

ABSTRACT

Accepted: 
13 Feb, 2017
PDF Attachment: 
Journal Sections: 
e-Published: 02 Mar, 2017

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