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M Saeed

Pharmacological Evaluation of Marginally Designed New Profen Analogues

DOI: 
10.7727/wimj.2016.400
Synopsis: 
This study was conducted for the pharmacological evaluation of some novel analogues of naproxen, flurbiprofen and ibuprofen, well established COX inhibitors, with the goal of identifying a COX inhibitor(s) with optimized potency and efficacy. The synthesized and characterized analogues were tested for their acute toxicity, anti-inflammatory, analgesic and antipyretic activities based on the reported bioassay models. Molecular docking analysis was also performed to predict ligand: protein interactions. The synthesized analogues have highly significant pharmacological activities and have the potential to be further explored as new drug molecules. 

ABSTRACT

Accepted: 
13 Feb, 2017
PDF Attachment: 
Journal Sections: 
e-Published: 02 Mar, 2017

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Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Clinical and Therapeutic Implications of Histone Acetylation in Breast Cancer

Issue: 
DOI: 
10.7727/wimj.2014.297
Pages: 
337-44
Synopsis: 
The role of epigenetic changes with special focus on histone modifying enzymes in breast cancer is explored. Blending both epigenetic anomalies and genome instability is suggested as useful tool for breast cancer diagnosis. A basic understanding of HAT and HDACs families is required in designing potential cancer therapeutics.

ABSTRACT

Accepted: 
24 Oct, 2014
PDF Attachment: 
Journal Sections: 
Journal Authors: 
e-Published: 06 May, 2015
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