immunohistochemistry methods

The Prognostic Importance of Immunohistochemical Biomarkers in Diffuse Large B-Cell Lymphoma

Issue:

Vol 69, Issue 1: 2021

DOI:

10.7727/wimj.2015.550

Pages:

38-43

Synopsis:

Patients with diffuse large B cell lymphoma (DLBCL) were sub-classified by immunohistochemical method to evaluate the effects of subgroups on prognosis. The lymph node biopsy specimens of 40 patients with DLBCL were stained with monoclonal antibody immunstains of CD10, Bcl-6 and MUM1. Finally, MUM1 was found negatively correlated with overall survival and event-free survival.

ABSTRACT

Objective: Molecular methods have practical difficulties in identifying sub-groups of diffuse large B-cell lymphoma (DLBCL) in routine clinical practice. The goal of this study was to subclassify DLBCL patients into sub-groups by immunohistochemical method and to evaluate the effects of sub-groups on prognosis.

Received:

05 Nov, 2015

Accepted:

16 Nov, 2015

Published:

30 Apr, 2021

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