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neurodegenerative disorder

Elevated Ferric, Calcium and Magnesium Ions in the Brain Induce Protein Aggregation in Brain Mitochondria

This study evaluated the impact of elevated aluminum, ferric, calcium and magnesium ions on rabbit brain. Aluminum ion, but not the others, induced neurofibrillary degeneration within the midbrain and medulla. On the other hand, the other three ions caused aggregation of low molecular weight mitochondrial proteins.



Objective: Alzheimer’s disease and Parkinson’s disease are two of several neurodegenerative disorders that affect the elderly. Although their aetiology remains uncertain, studies suggest that elevated aluminium or other metal ions in the brain directly influence the development of the histological abnormalities normally associated with these diseases; other investigations suggest that metal-ioninduced-dysfunction of mitochondria might be a critical factor.

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e-Published: 19 Aug, 2013
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