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T Alleyne

Short Term Effects of Cocoa Consumption on Blood Pressure

Issue: 
DOI: 
10.7727/wimj.2013.273
Pages: 
312–7
Synopsis: 
Previous studies showed that prolonged consumption of cocoa led to a decrease in blood pressure; however, whether cocoa consumption exerted an immediate effect on high blood pressure was unknown. This study showed that within an hour of consumption, a single intervention of cocoa induced decreases in both the diastolic and systolic blood pressures that were significant.

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Accepted: 
30 Oct, 2013
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e-Published: 02 Dec, 2013

Early Electron Transfer in Cytochrome c oxidase Occurs by a Chymotrypsin Type Relay

Issue: 
Pages: 
499–505
Synopsis: 
This computer based study leads to the conclusion that electrons arriving at the surface of cytochrome c oxidase migrate to the enzyme’s first active centre by a hydride ion relay system similar to that seen at the active site of chymotrypsin.

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e-Published: 20 Sep, 2013

Elevated Ferric, Calcium and Magnesium Ions in the Brain Induce Protein Aggregation in Brain Mitochondria

Issue: 
Pages: 
122–7
Synopsis: 
This study evaluated the impact of elevated aluminum, ferric, calcium and magnesium ions on rabbit brain. Aluminum ion, but not the others, induced neurofibrillary degeneration within the midbrain and medulla. On the other hand, the other three ions caused aggregation of low molecular weight mitochondrial proteins.

 

ABSTRACT

Objective: Alzheimer’s disease and Parkinson’s disease are two of several neurodegenerative disorders that affect the elderly. Although their aetiology remains uncertain, studies suggest that elevated aluminium or other metal ions in the brain directly influence the development of the histological abnormalities normally associated with these diseases; other investigations suggest that metal-ioninduced-dysfunction of mitochondria might be a critical factor.

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e-Published: 19 Aug, 2013

Hydrogen/hydride Ion Relay – A Mechanism for Early Electron Transfer in Cytochrome c Oxidases

Issue: 
DOI: 
10.7727/wimj.2012.120
Pages: 
3–11
Synopsis: 
Cytochrome c oxidase (COX) employs electrons obtained from cytochrome c to reduce oxygen to water. Recently, we proposed that electrons travel from cytochrome c to CuA of COX, by a hydrogen/hydride ion relay. Now, on the basis of a similar computer study, we conclude that this hydride/hydrogen ion mechanism is common to other oxidases.

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e-Published: 09 Apr, 2013

Marginally Low Copper Causes Lesions of the Midbrain in Animal Models: The Implications for Man

Issue: 
Pages: 
481–6
Synopsis: 
There were pathological changes in the midbrain of young sheep and rabbit with low serum copper.

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e-Published: 04 Jul, 2013

The Control of Hypertension by use of Coconut Water and Mauby: Two Tropical Food Drinks

Issue: 
Pages: 
3–8
Synopsis: 
A study was carried out to determine if coconut water and/or mauby possess haemodynamic properties. It was found that regular consumption of these two drinks led to significantly decreased blood pressure in 40 – 70% of the subjects studied. Some very large decreases were seen when the two drinks were mixed before consumption.


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e-Published: 04 Jun, 2013

The Effects of Ingested Aluminium on Brain Cytochrome Oxidase Activity

Issue: 
Pages: 
422–7
Synopsis: 
When rabbits were maintained on a diet supplemented with aluminium, a 35% decrease in brain cytochrome c oxidase activity (COX) was observed. Isolation of number of the enzyme’s low molecular weight subunits was absent.

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e-Published: 20 Sep, 2013

Probing the Specifics of Substrate Binding for Cytochrome c Oxidase A Computer Assisted Approach

Issue: 
Pages: 
54–60
Synopsis: 
Transfer of electrons from ferrocytochrome C to cytochrome c oxidase is facilated by enzyme-substrate complexes stabilized by salt bridges. Computer simulations were employed to identify residues that participate in intermolecular salt bridges.

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e-Published: 17 Sep, 2013
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