An eight and half-year old girl was referred to endocrinology outpatient clinic due to onset of puberty. There was consanguinity between parents who had no history of such disease. She had a ventriculoperitoneal shunt due to congenital hydrocephaly.
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The most important finding was the determination of body composition and hormonal measurement changes in puberty in boys. Oestradiol was the most potent determinant of bone mineral density among pubertal boys.