Objectives: Aflatoxicosis is a mycotoxicosis infection with an acute or chronic course that forms due to aflatoxins (AFs) in humans and animals. Aflatoxins primarily affect the liver and can lead to histopathological necrosis, fibrosis and hepatocarcinogenesis of the organ. According to previous studies, the antioxidant, immunomodulator and anticancerogenic effects of dead nettle are well known. By contrast, the present report studies the preventive effects of dead nettle extract on liver lesions that were induced by experimental aflatoxicosis in rats.
Materials and Methods: Total of 30 rats were separated into three groups of 10 rats each. Experimental group A (control) received normal rat food, experimental group B (AFB1) received 2 mg/kg of AF, and experimental group C (AFB1+IOY) received 2 mg/kg of AF + 2 ml/rat/day with added dead nettle leaf extract. After three months of experimentation, blood and tissue samples were taken from the rats by necropsy in order to perform chemical and histopathological analyses.
Results: According to the biochemical and histopathological findings of this report, antioxidant system activity increased and lipid peroxidation and liver enzyme levels decreased in the group that received IOY extract.
Conclusion: IOY has hepatoprotective effects against aflatoxicosis.
This manuscript has been assigned to a volume and issue but has not yet been published. It is either being edited, typeset or is in the proof stage of publication.
In the pre-published stage, this manuscript may contain statements, opinions, and information that have errors in facts, figures, or interpretation. Any final changes in this manuscript will be made at the time of publication and will be reflected in the final electronic version of the issue. The editors and authors and their respective employees are not responsible or liable for the use of any such inaccurate or misleading data, opinion or information contained in the articles in this section.