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Immunohistopathological and Biochemical Study of the Effects of Dead Nettle (Urtica Dioica) Extract on Preventing Liver Lesions Induced by Experimental Aflatoxicosis in Rats

Journal Authors: 
Issue: 
DOI: 
10.7727/wimj.2016.126

ABSTRACT

Objectives: Aflatoxicosis is a mycotoxicosis infection with an acute or chronic course that forms due to aflatoxins (AFs) in humans and animals. Aflatoxins primarily affect the liver and can lead to histopathological necrosis, fibrosis and hepatocarcinogenesis of the organ. According to previous studies, the antioxidant, immunomodulator and anticancerogenic effects of dead nettle are well known. By contrast, the present report studies the preventive effects of dead nettle extract on liver lesions that were induced by experimental aflatoxicosis in rats.

Materials and Methods: Total of 30 rats were separated into three groups of 10 rats each. Experimental group A (control) received normal rat food, experimental group B (AFB1) received 2 mg/kg of AF, and experimental group C (AFB1+IOY) received 2 mg/kg of AF + 2 ml/rat/day with added dead nettle leaf extract. After three months of experimentation, blood and tissue samples were taken from the rats by necropsy in order to perform chemical and histopathological analyses.

Results: According to the biochemical and histopathological findings of this report, antioxidant system activity increased and lipid peroxidation and liver enzyme levels decreased in the group that received IOY extract.

Conclusion:  IOY has hepatoprotective effects against aflatoxicosis.

Accepted: 
25 May, 2016
e-Published: 13 Jul, 2016

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