This paper studied the preventive effects of dead nettle extract on liver lesions that were induced by experimental aflatoxicosis in rats. According to the biochemical and histopathological findings of the study, antioxidant system activity increased and lipid peroxidation and liver enzyme levels decreased in the group that received dead nettle leaf extract. As a result, it could be concluded that dead nettle leaf extract had hepatoprotective effects against aflatoxicosis.