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B Willey

16S rRNA Methyltransferases in Clinical Gram-negative Bacilli from a Tertiary Care Hospital in the Caribbean

16S rRNA methyltransferase enzymes pose an iminent threat to the availability of aminoglycosides as an emipiric therapeutic option for Gram negative bacterial infections. Their presence in the Caribbean therfore further burdens this resource limited region.



Objective: 16S rRNA methyltransferase enzymes or RMT confer pan-resistance to the aminoglycoside class of antibiotics. Multidrug-resistant Gram-negative bacilli with these methyltransferase genes have been identified from clinical settings in Europe, Asia and the Americas. This study reports their detection and characterization in Jamaican Multidrug-resistant Gram-negative bacilli.

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e-Published: 08 Mar, 2019


Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

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