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16S rRNA Methyltransferases in Clinical Gram-negative Bacilli from a Tertiary Care Hospital in the Caribbean

DOI: 
10.7727/wimj.2018.131
Pages: 
Synopsis: 
16S rRNA methyltransferase enzymes pose an iminent threat to the availability of aminoglycosides as an emipiric therapeutic option for Gram negative bacterial infections. Their presence in the Caribbean therfore further burdens this resource limited region.

ABSTRACT

 

Objective: 16S rRNA methyltransferase enzymes or RMT confer pan-resistance to the aminoglycoside class of antibiotics. Multidrug-resistant Gram-negative bacilli with these methyltransferase genes have been identified from clinical settings in Europe, Asia and the Americas. This study reports their detection and characterization in Jamaican Multidrug-resistant Gram-negative bacilli.

PDF Attachment: 
Journal Sections: 
e-Published: 08 Mar, 2019

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Agreement, Time and Cost Comparison for the Identification of Gram Negative Bacteria Isolates Using VITEK® 2 Compact, VITEK® 60, VITEK® Mass Spectrometry and API® 20E/NE

DOI: 
10.7727/wimj.2017.139
Synopsis: 
This study looked at the agreement between Vitek®2 Compact (VTC), VITEK®2 60 (VT60), API® 20E/20NE (API) and VITEK® MS (VMS) bacteria identification systems (ID). It also examined the time and cost for the relevant bacterial ID systems and the resolution of discrepancies which arose as a result of using the different systems, mainly in Canada but also with reference to the Vitek®2 Compact (VTC) in Mona, Jamaica.

ABSTRACT

Objectives: We aimed to compare systems in respect of 1) the agreement between VITEK®2 Compact, VITEK®2 60, VITEK® Mass Spectrometry systems and API®20E/NE for species identification, 2) the time to identification of organisms and 3) the cost of identification and susceptibility testing of each organism.

Accepted: 
12 Dec, 2017
Journal Sections: 
e-Published: 13 Dec, 2017

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Meropenem Efflux in Pseudomonas aeruginosa at a Tertiary Care Hospital in Jamaica

Issue: 
DOI: 
10.7727/wimj.2016.022
Pages: 
105-9
Synopsis: 
This article examined efflux as a mechanism of carbapenem resistance in Pseudomonas aeruginosa isolates at a hospital in Jamaica. The study detected that 80% of the isolates tested had efflux as a mechanism of resistance to meropenem.

ABSTRACT

Objective: Several mechanisms account for carbapenem resistance in Pseudomonas (P.) aeruginosa which is an emerging problem at a tertiary care hospital (TCH) in Jamaica.  The observed pattern of carbapenem resistance that results from efflux mechanisms is unique because it is specific to meropenem (MEM).  Investigation of efflux as a mechanism of carbapenem resistance needed to be done as the information obtained could inform therapeutic and infection control strategies.

Accepted: 
21 Jan, 2016
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Journal Sections: 
e-Published: 01 Mar, 2016

Detection of OXA Carbapenemase Positive Acinetobacter spp., Jamaica

DOI: 
10.7727/wimj.2016.065
Synopsis: 
This article looks at the mechanism of carbapenem resistance and clonality of multidrug resistant Acinetobacter spp. at a hospital in Jamaica. PCR found that many of these isolates, some of which are clonally related, were carbapenemase producers.

ABSTRACT

Objective:  The global problem of resistance to carbapenem antibiotics, through the production of carbapenemases by clinically significant bacteria, continues to increase while options for antibiotic therapy remain limited. It is important to determine the mechanism of carbapenem resistance in the multidrug resistant (MDR) Acinetobacter spp.  isolated at a tertiary care hospital, Jamaica (TCHJ) because of the implications for therapy which is the goal of this study.

Accepted: 
20 Apr, 2016
PDF Attachment: 
Journal Sections: 
e-Published: 27 Apr, 2016

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Antinuclear Antibodies and HLA Class II Alleles in Jamaican Patients with Systemic Lupus Erythematosus

Issue: 
Pages: 
130–3
Synopsis: 
A cross-sectional study in which DNA HLA typing methods were used to investigate the associations between HLA and class II alleles and the presence of systemic lupus erythematosus and antinuclear antibodies (ANA) in Jamaicans. The HLA associations with ANA were similar to those found in other ethnic groups, but no significant positive HLA association with SLE was found.

ABSTRACT

Objective: The relationship between human leukocyte antigens class II (HLA) and antinuclear antibodies
was investigated in Jamaican patients with Systemic Lupus Erythematosus (SLE).

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e-Published: 01 Jul, 2013

Aminoglycoside Resistance in Clinical Isolates of Gram Negative Bacilli at the University Hospital of the West Indies, Jamaica: Comparison of Two Time Periods

Issue: 
DOI: 
10.7727/wimj.2014.040
Pages: 
87–91
Synopsis: 
Aminoglycosides have been in use at the University Hospital of The West Indies for over 30 years. This report answers the question of their continued usefulness by comparing current resistance rates with previously collected data.

ABSTRACT

Accepted: 
28 Feb, 2014
PDF Attachment: 
Journal Sections: 
e-Published: 12 Feb, 2015

Epidemiology of Coagulase-Negative Staphylococci Isolated from Clinical Blood Specimens at the University Hospital of the West Indies

Issue: 
Pages: 
170–3
Synopsis: 
This report is on the prevalence and significance of coagulase negative Staphylococci isolated from blood cultures of patients seen at the University Hospital of the West Indies, Kingston, Jamaica, over a six month period.

ABSTRACT

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e-Published: 10 Jun, 2013
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