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K Feng

Comparative Proteomic Analysis of the Nucleus Accumbens during Extinction and Reinstatement of Morphine Dependence

Issue: 
DOI: 
10.727/wimj.2013.085
Pages: 
210–5
Synopsis: 
The aim of this study was to detect differentially expressed proteins in the nucleus accumbens between the states of extinction and reinstatement of morphine addiction. Significant changes in five proteins were detected between extinction and reinstatement. These proteins are correlated with phosphorylation and the tricarboxylic acid cycle.

ABSTRACT


Background: The aim of this study was to detect differentially expressed proteins in the nucleus accumbens between the states of extinction and reinstatement of morphine addiction. Numerous studies on the neurobiological mechanisms concerning drug craving and relapse have been reported to date, but data on their relationship with the underlying key molecular mechanisms involved remain limited.

Accepted: 
02 Apr, 2013
PDF Attachment: 
Journal Sections: 
e-Published: 26 Jun, 2013
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