Close Menu

conditioned place preference

Dosage and Conditioning Period Determine Reward or Aversion to Cannabis-induced Conditioned Place Preference in Sprague-Dawley Rats

Issue: 
DOI: 
10.7727/wimj.2017.185
Pages: 
523-8
Synopsis: 
The study demonstrated that a shortened conditioning period of 18 minutes in the conditioned place preference paradigm could induce significant delta-9-tetrahydrocannabinol (∆9-THC) reward at low doses, supporting the addictive potential of the psychoactive agent of marijuana. This is the first report of significant reward at a dose of 0.05 mg/kg of ∆9-THC in an animal model of addiction.

ABSTRACT

Objective: To assess the addictive potential of cannabis by investigating the motivational responses to low doses of delta-9-tetrahydrocannabinol (Δ9-THC) and a marijuana tea extract (MTE), and to determine if the length of the conditioning period in the conditioned place preference (CPP) paradigm influences reward or aversion to these cannabinoid preparations.

Accepted: 
23 Oct, 2017
PDF Attachment: 
Journal Sections: 
Journal Authors: 
e-Published: 19 Dec, 2017
Subscribe to RSS - conditioned place preference
Top of Page