M Taherahmadi

Performance Assessment of the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism Method for Rapid Detection of Susceptibility to Ethambutol and Molecular Prediction of XDR Tuberculosis in Clinical Isolates of Mycobacterium tuberculosis

Issue:

Vol 64, Issue 4: September (2015)

DOI:

10.7727/wimj.2014.022

Pages:

325–32

Synopsis:

Fast detection of susceptibility to ethambutol drug is possible by polymerase chain reaction-restriction fragment length polymorphism. The embB306 locus is a candidate marker for rapid prediction of high resistance to anti-tuberculosis drugs for multidrug and extensively drug resistant forms of tuberculosis.

ABSTRACT

Introduction: The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was employed for rapid detection of ethambutol (EMB) resistant clinical isolates of Mycobacterium tuberculosis.

Received:

03 Feb, 2014

Accepted:

19 Jun, 2014

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