NN Nwobodo

Simvastatin Enhances Clinical Response of Patients to Sulfadoxine-Pyrimethamine in Falciparum Malaria

DOI:

10.7727/wimj.2015.061

Synopsis:

This study was conducted to evaluate falciparum malaria patients' clinical response of simvastatin in combination with sulfadoxine-pyrimethamine. It was concluded that simvastatin is a potential candidate for combinational anti-malarial chemotherapy.

ABSTRACT

Background: Doubts have been raised concerning the therapeutic efficacy of sulfadoxine-pyrimethamine due to poor clinical response necessitating the need for continuous monitoring and further advocating for the replacement of sulfadoxine-pyrimethamine with suitable alternatives. Statins are known to down regulate biosynthesis of dolichol and isoprenoid pyrophosphate, inhibiting in vitro growth of Plasmodium falciparum.^.

Received:

29 Jan, 2015

Accepted:

23 Nov, 2015

PDF Attachment:

nwobodo20et20al-simvastatin20enhances20clinical20response1.pdf

Journal Sections:

Original Articles

Keywords:

Malaria

simvastatin

Plasmodium falciparum

Sulfadoxine-pyrimethamine

Treatment failure.

Journal Authors:

NN Nwobodo

PO Okonkwo

e-Published: 18 Feb, 2016

Read more about Simvastatin Enhances Clinical Response of Patients to Sulfadoxine-Pyrimethamine in Falciparum Malaria

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Simvastatin Modulates Parasitological Response to Sulfadoxine-pyrimethamine in Acute, Uncomplicated Malaria

DOI:

10.7727/wimj.2015.416

Synopsis:

The present study, which was aimed at evaluating the effects of simvastatin in modulating parasitological response to sulphadoxine-pyrimethamine, revealed that the significant improvement in parasitological response may be attributed to simvastatin use.

ABSTRACT

Background: Mutations in parasite enzymes and sub-optimal dosing associated with poor quality drug administration are considered major causes of parasitological resistance to sulfadoxine-pyrimethamine in the treatment of malaria.

Objectives: This study evaluated the effects of simvastatin in modulating parasitological response to sulfadoxine-pyrimethamine in the treatment of malaria.