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Malaria

Estimated Effects of Climate Variables on Transmission of Malaria, Dengue and Leptospirosis within Georgetown, Guyana

DOI: 
10.7727/wimj.2017.118
Pages: 
Synopsis: 
The study suggest a connection between climate variable and vector borne disease. The study showed a positive correlation between climate variables and vector borne diseases like malaria, leptospirosis and dengue.

ABSTRACT

Objective: To analyze meteorological data (temperature, rainfall and relative humidity) and vector borne diseases (malaria, dengue and leptospirosis) to determine trends that may exist between and among variables within the Georgetown area.

Received: 
02 Jun, 2017
Accepted: 
07 Jul, 2017
PDF Attachment: 
PDF icon boston_and_kurup-transmission_of_vector_borne_diseases.pdf
Journal Sections: 
Original Articles
Keywords: 
Dengue
Climate Change
Leptospirosis
Malaria
Journal Authors: 
C Boston
R Kurup
e-Published: 07 Jul, 2017

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

The Relationship between Body Composition and Renal Resistive Index in New-diagnosed Hypertensive Patients

Issue: 
Vol 66, Issue 2: 2017
DOI: 
10.7727/wimj.2015.054
Pages: 
256–61
Synopsis: 
The objective of this study was to examine the relationship between body composition and arterial stiffness documented by Doppler-derived renal resistive index (RRI). Independent factors affecting RRI were age, gender, BFP and CRP levels (all p-values were <0.05). Altered renal hemodynamic profile is involved in the long-term renal risk associated with body fat distribution.

ABSTRACT

Objective: Obesity is a major modifiable risk factor for atherosclerosis. Thus, early risk markers are needed to identify obese subjects. The objective of this study was to examine the relationship between body composition and arterial stiffness documented by Doppler-derived renal resistive index (RRI).

Received: 
28 Jan, 2015
Accepted: 
23 Nov, 2015
Published: 
22 Sep, 2017
PDF Attachment: 
PDF icon wimj-iss2-2017_256_261.pdf
Journal Sections: 
Original Articles
Keywords: 
Malaria
simvastatin
Plasmodium falciparum
Clinical response
Fever clearance
Parasite clearance
Recrudescence
Sulfadoxine-pyrimethamine
Treatment failure.
Journal Authors: 
S Karakan
B Inan
e-Published: 18 Feb, 2016

Simvastatin Enhances Clinical Response of Patients to Sulfadoxine-Pyrimethamine in Falciparum Malaria

DOI: 
10.7727/wimj.2015.061
Synopsis: 
This study was conducted to evaluate falciparum malaria patients' clinical response of simvastatin in combination with sulfadoxine-pyrimethamine. It was concluded that simvastatin is a potential candidate for combinational anti-malarial chemotherapy.

ABSTRACT

Background: Doubts have been raised concerning the therapeutic efficacy of sulfadoxine-pyrimethamine due to poor clinical response necessitating the need for continuous monitoring and further advocating for the replacement of sulfadoxine-pyrimethamine with suitable alternatives. Statins are known to down regulate biosynthesis of dolichol and isoprenoid pyrophosphate, inhibiting in vitro growth of Plasmodium falciparum..

Received: 
29 Jan, 2015
Accepted: 
23 Nov, 2015
PDF Attachment: 
PDF icon nwobodo20et20al-simvastatin20enhances20clinical20response1.pdf
Journal Sections: 
Original Articles
Keywords: 
Malaria
simvastatin
Plasmodium falciparum
Clinical response
Fever clearance
Parasite clearance
Recrudescence
Sulfadoxine-pyrimethamine
Treatment failure.
Journal Authors: 
NN Nwobodo
PO Okonkwo
e-Published: 18 Feb, 2016

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Liver Function Status of Malaria Patients in Benin-City, Nigeria

Issue: 
Vol 65, Issue 3: 2016
DOI: 
10.7727/wimj.2014.127
Pages: 
492-95
Synopsis: 
We conclude from our findings that hepatocyte function is increasingly compromised as malaria severity increases.

ABSTRACT

Received: 
21 May, 2014
Accepted: 
18 Sep, 2014
PDF Attachment: 
PDF icon wimj_iss3_2016_492_495.pdf
Journal Sections: 
Original Articles
Keywords: 
Malaria
aminotransferases
parasitaemia
total protein
Journal Authors: 
EC Onyeneke
EI Oikeh
A Obhakhan
e-Published: 14 Jan, 2016

Healthcare Utilization for Acute Febrile Illness, Knowledge of Malaria and Trust in Informational Resources among Clinic Attendees in Port-au-Prince and Artibonite Département: A Cross-sectional Survey

DOI: 
10.7727/wimj.2015.231
Synopsis: 
A clinic-based cross-sectional survey was conducted during 2012–13 in Port-au-Prince and Artibonite Département, Haiti to assess the utilization of health facilities and treatment options for acute febrile illness (AFI), knowledge of malaria, and types and trust in malaria information sources.

ABSTRACT

Objective: The overall aim of the project was to understand healthcare utilization patterns and access to and trust in resources regarding malaria and other febrile illness in two regions (Port-au-Prince and Artibonite Département) differentially affected by the 2010 earthquake.

Received: 
06 May, 2015
Accepted: 
18 May, 2015
PDF Attachment: 
PDF icon kaljee20et20al-healthcare20utilization20for20afi20haiti1.pdf
Journal Sections: 
Original Articles
Keywords: 
Malaria
Haiti
Acute Febrile Illness
Healthcare Utilization
Journal Authors: 
LM Kaljee
P Kilgore
M Zervos
J Zervos
D Parke
S Arshad
C Chan
T Prentiss
K Prentiss
J Sime
e-Published: 11 Nov, 2015

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Simvastatin Modulates Parasitological Response to Sulfadoxine-pyrimethamine in Acute, Uncomplicated Malaria

DOI: 
10.7727/wimj.2015.416
Synopsis: 
The present study, which was aimed at evaluating the effects of simvastatin in modulating parasitological response to sulphadoxine-pyrimethamine, revealed that the significant improvement in parasitological response may be attributed to simvastatin use.

ABSTRACT

Background: Mutations in parasite enzymes and sub-optimal dosing associated with poor quality drug administration are considered major causes of parasitological resistance to sulfadoxine-pyrimethamine in the treatment of malaria.

Objectives: This study evaluated the effects of simvastatin in modulating parasitological response to sulfadoxine-pyrimethamine in the treatment of malaria.

Received: 
03 Aug, 2015
Accepted: 
11 Sep, 2015
PDF Attachment: 
PDF icon nwobodo20et20al-simvastatin20enhances20clinical20response1.pdf
Journal Sections: 
Original Articles
Keywords: 
Malaria
simvastatin
HMG-CoA reductase inhibitor
Parasite resistance
Parasitological response
Plasmodium falciparum
Journal Authors: 
NN Nwobodo
PO Okonkwo
e-Published: 03 Nov, 2015

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Specificity of Vascular Reactivity and Altered Response in Experimental Malaria

Issue: 
Vol 60, Issue 3 (2011)
Pages: 
330–5
Synopsis: 
The direct interaction between the parasitized erythrocytes and vascular endothelial cells altered contractile responses in vascular rings. The regulation of vascular tone by various vasoactive agents following exposure to malaria parasites might be altered in a vessel-specific manner.

ABSTRACT

Objective: Adherence of erythrocytes infected with Plasmodium falciparum (P falciparum) to microvascular endothelial cells (sequestration) is considered to play an important role in parasite virulence and pathogenesis. In this study, we have examined the possibility that there is altered vascular reactivity due to the direct interaction between the parasitized erythrocytes and vascular endothelial cells and that it could be tissue specific.

PDF Attachment: 
PDF icon dr_cr_nwokocha.qxd_.pdf
Journal Sections: 
Original Articles
Keywords: 
Malaria
vascular reactivity
vessel specificity
Journal Authors: 
CR Nwokocha
IO Ajayi
DU Owu
AB Ebeigbe
e-Published: 31 Jan, 2014

Altered Vascular Reactivity Induced By Malaria Parasites

Issue: 
Vol 60, issue 1 (2011)
Pages: 
13–8
Synopsis: 
The direct interaction between the parasitized erythrocytes and vascular endothelial cells altered contractile responses in aortic rings of rats.

Objective: In this study, we have examined the possibility that there is altered vascular reactivity due to the direct interaction between parasitized erythrocytes and vascular endothelial cells.

PDF Attachment: 
PDF icon dr_nwokocha.qxd_.pdf
Journal Sections: 
Original Articles
Keywords: 
vascular
Malaria
reactivity
tissue specificity
Journal Authors: 
CR Nwokocha
IO Ajayi
AB Ebeigbe
e-Published: 17 Oct, 2013

Malaria: Morbidity, Mortality and its Associated Complications

Issue: 
Vol 60, issue 1 (2011)
Pages: 
1–2

INTRODUCTION

PDF Attachment: 
PDF icon editorial_dr_ibanga.qxd_.pdf
Journal Sections: 
Editorial
Keywords: 
Malaria
Journal Authors: 
IA Ibanga
CR Nwokocha
e-Published: 17 Oct, 2013

Malaria and its Vectors in the Caribbean: The Continuing Challenge of the Disease Forty-Five Years after Eradication from the Islands

Issue: 
Vol 57, Issue 5 (2008)

                                                                     ABSTRACT

Objectives: Given the occurrence of autochthonous malaria in non-endemic island countries in the last 10 years, this study evaluates the risk factors for malaria transmission in the malaria “endemic and “non-endemic” countries of the Caribbean region.

PDF Attachment: 
PDF icon rawlins_malaria_and_its_vectors_in_the_caribbean_the_continuing_challenge_of_the_disease_forty_five_years_after.pdf
Journal Sections: 
Original Articles
Keywords: 
Caribbean
Malaria
Vectors
Journal Authors: 
SC Rawlins
A Hinds
JM Rawlins
e-Published: 24 Jul, 2013

Pre-published Manuscript

This manuscript has been assigned to a volume and issue but has not yet been published. It is either being edited, typeset or is in the proof stage of publication.
In the pre-published stage, this manuscript may contain statements, opinions, and information that have errors in facts, figures, or interpretation. Any final changes in this manuscript will be made at the time of publication and will be reflected in the final electronic version of the issue. The editors and authors and their respective employees are not responsible or liable for the use of any such inaccurate or misleading data, opinion or information contained in the articles in this section.

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