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ZD Mulla

Spline Regression in Clinical Research

Issue: 
Pages: 
77–9
Synopsis: 
An introduction to the simple technique of spline regression is provided using data from a study of patients hospitalized for invasive group A streptococcal disease. A spline model is used to examine the dose-response association between serum albumin and mortality.

ABSTRACT

Objective: The objective of this article is to illustrate the statistical technique of spline regression, an under-utilized tool in clinical research. Spline regression was used to assess the dose-response association between serum albumin and hospital mortality.

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e-Published: 01 Jul, 2013
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