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Angiotensin-converting enzyme inhibitors

Reduced Frequency of Bone Pain Crises in Patients with Sickle Cell Disease Given an Angiotensin-converting Enzyme Inhibitor

Issue: 
DOI: 
10.7727/wimj.2018.137
Pages: 
24-8
Synopsis: 
Bone pain is a chronic debilitating feature of sickle cell disease requiring opioid analgesia with a risk of addiction. Angiotensin-converting enzyme inhibition whose benefit was previously reported in the West Indies was tried in a Nigerian cohort and was found to be encouraging.

ABSTRACT

Objective: To determine if sickle cell disease (SCD) bone pain crisis is mitigated by use of an angiotensin-converting enzyme inhibitor (ACEI), following a case report of ACEIs preventing bone pain crisis.

Accepted: 
26 Dec, 2018
PDF Attachment: 
Journal Sections: 
e-Published: 25 Mar, 2019
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