This paper provides an overview of the development of an institution-specific antibiogram, looking at last-line antibiotics, such as carbapenems. This provides an epidemiological trend for the entire institution. Patients’ specific antibiograms and unit-specific trends (eg intensive care units, surgical wards and outpatient clinics) can be used as a guide in patients with less severe infections. Thus, these recommendations should be tailored, as appropriate. This will help reduce the development of resistance when treating any patient for whom swabs, blood or urine are submitted.