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Carbapenem Resistance in Gram-negative Bacteria in South-western Nigeria: The Role of Extended-spectrum β-lactamase CTX-M-15

Issue: 
DOI: 
10.7727/wimj.2017.122
Pages: 
344-9
Synopsis: 
A previous study by the authors identified carbapenemases as a cause of carbapenem resistance in Gram-negative bacteria from Nigeria. There remained carbapenem-resistant isolates without production of a carbapenemase. This study demonstrated that extended-spectrum β-lactamases (largely CTX-M-15) with protein loss was an important mechanism underpinning carbapenem resistance.

ABSTRACT

Objective: To determine the role of extended-spectrum β-lactamases in carbapenem-resistant Gram-negative bacteria from south-western Nigeria.

Accepted: 
15 Dec, 2017
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Journal Authors: 
e-Published: 18 Dec, 2017

Meropenem Efflux in Pseudomonas aeruginosa at a Tertiary Care Hospital in Jamaica

Issue: 
DOI: 
10.7727/wimj.2016.022
Pages: 
105-9
Synopsis: 
This article examined efflux as a mechanism of carbapenem resistance in Pseudomonas aeruginosa isolates at a hospital in Jamaica. The study detected that 80% of the isolates tested had efflux as a mechanism of resistance to meropenem.

ABSTRACT

Objective: Several mechanisms account for carbapenem resistance in Pseudomonas (P.) aeruginosa which is an emerging problem at a tertiary care hospital (TCH) in Jamaica.  The observed pattern of carbapenem resistance that results from efflux mechanisms is unique because it is specific to meropenem (MEM).  Investigation of efflux as a mechanism of carbapenem resistance needed to be done as the information obtained could inform therapeutic and infection control strategies.

Accepted: 
21 Jan, 2016
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e-Published: 01 Mar, 2016

What are the Roles of Carbapenems, in an Institution Specific Epidemiological Antibiogram, in East Trinidad?

DOI: 
10.7727/wimj.2015.225
Synopsis: 
This document provides an overview of the development of an institution-specific antibiogram, looking at last line antibiotics, such as carbapenems. This provides an epidemiological trend for the entire institution. Patients' specific antibiograms and unit specific trends [e.g. ICU, surgical wards, and outpatient clinic] can be used as a guide in the patients with less severe infections. Thus, these recommendations should be tailored, as appropriate. This will help reduce the development of resistance when treating any patient for which, swabs, blood or urine are submitted.

ABSTRACT

Objectives: This document provides an overview of the development of an institution specific epidemiological antibiogram. Emphasis was on last line antibiotics, such as carbapenems.    

Accepted: 
18 May, 2015
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Journal Sections: 
e-Published: 10 Nov, 2015

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Beta-lactamase Enzymes of Clinical Pseudomonas aeruginosa Strains

Issue: 
DOI: 
10.7727/wimj.2014.362
Pages: 
40–5
Synopsis: 
The resistance of Pseudomonas aeruginosa occurred pending treatment of patients, is a great danger. Detection of beta-lactamases and monitoring antibiotic susceptibilities are extremely important for the selection of appropriate empirical antibiotic therapy in P aeruginosa infections.

ABSTRACT

Objectives: In this study, the production of extended spectrum beta-lactamase (ESBL), metallo-beta-lacatamase (MBL) and AmpC beta-lactamase enzymes of Pseudomonas aeruginosa (P aeruginosa) strains which were isolated from clinical samples were investigated. AmpC gene was also detected by the polymerase chain reaction (PCR) analysis.

Accepted: 
12 Dec, 2014
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Journal Sections: 
e-Published: 16 Jun, 2015

A Case of Graves' Disease Resistant to Carbimazole

DOI: 
10.7727/wimj.2016.266

ABSTRACT

Accepted: 
14 Jul, 2016
PDF Attachment: 
Journal Sections: 
Journal Authors: 
e-Published: 03 Aug, 2016

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

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