CCAAT enhancer binding protein α

The Role of FLT3-ITD and CCAAT-Enhancer-Binding Protein α Mutations on Prognosis of Acute Lymphoblastic Leukaemia in Turkish Patients

Issue:

Vol 69, Issue 7: 2022

DOI:

10.7727/wimj.2015.446

Pages:

494-8

Synopsis:

In this article, we evaluated the prognostic value of FLT3-ITD and CCAAT-enhancer-binding protein α (CEBPA) mutations in acute lymphoblastic leukaemia. We did not detect any relationship between FLT3-ITD and CEBPA mutations as prognostic factors. However, FLT3-ITD mutation may affect the response to chemotherapy.

ABSTRACT

Background: Acute lymphoblastic leukaemia (ALL) is the most common malignancy in childhood. Although some prognostic factors have been defined to date, the estimation of prognosis is currently not perfect. Previous studies had shown an association of FLT3 with poor prognosis and CCAAT-enhancer-binding protein α (CEBPA) mutation with the development of acute myeloid leukaemia (AML). Here, we aimed to evaluate the prognostic value of FLT3-ITD and CEBPA mutations in ALL.

Received:

17 Aug, 2015

Accepted:

08 Sep, 2015

Published:

02 May, 2022

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