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chromosome abnormality

The Application of Chromosome Abnormality Chip Detection in Male Infertility

Chromosome abnormality chip detection system provides a sensitive, economic and high-throughput method for detecting the deletion or amplification of genomic DNA sequences of infertile patients.


Objective: To discuss the application of microarray technology in the diagnosis of male infertility.

Methods: Sixteen loci, including a sex-determining region on the Y chromosome, were investigated by polymerase chain reaction (PCR) in infertile male patients. Chromosome abnormality chip with 180 000 probes was used to detect small deletion, small amplification and loss of heterozygosity.

20 Aug, 2013
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e-Published: 02 Apr, 2014

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