An increase in gingival blood flow (GBF) value was noted in the chronic periodontitis group with Type 2 diabetes mellitus compared with the group with chronic periodontitis only. Diabetes can also affect GBF due to the nature of the disease, which affects the microcirculatory status.

Platelet activating factor acetylhydrolase (PAF-AH) is detectable in gingival crevicular fluid by enzyme-linked immunosorbent assay (ELISA) and showed a continuous decrease following phase I periodontal therapy. Changes in the PAF-AH activity would be a progressive marker of periodontal healing to evaluate the success of periodontal therapies.