This study aimed to investigate the correlations between polymorphisms at position 49 in exon 1 and position 318 in the promoter of the cytotoxic T lymphocyte-associated antigen 4 gene and autoimmune thyroid diseases in a Han Chinese population. This had not been reported before.

Sex hormone-binding globulin gene polymorphisms are associated with higher risk of Type 2 diabetes mellitus in Egyptian men, through lowering circulating levels of sex hormone-binding globulin and consequently lowering testosterone and elevating oestradiol levels, which may be linked to insulin resistance.