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hyperglycaemia

Diabetic Hyperglycaemia Protects Smooth Muscle Arterial Cells but Not Macrophages and Endothelial Cells from the Cytotoxic Effects of 7-Ketocholesterol: An In Vitro Study

Issue: 
DOI: 
10.7727/wimj.2016.499
Pages: 
483-7
Synopsis: 
In the study reported, macrophages, smooth muscle and endothelial arterial cells were challenged against different concentrations of 7-ketocholesterol in normoglycemic and high glucose conditions. The hyperglycaemic medium protects only smooth muscle artery cells against the cytotoxic effects of 7-ketocholesterol.

ABSTRACT

Accepted: 
18 Dec, 2017
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Journal Sections: 
e-Published: 23 Jan, 2018

Antidiabetic Evaluation of Momordica charantia L Fruit Extracts

Issue: 
DOI: 
10.7727/wimj.2013.180
Pages: 
294–9
Synopsis: 
Antidiabetic activities (hypoglycaemic, hypolipidaemic and pancreatic beta cells regeneration) of Momordica charantia (MC) fruits were investigated in alloxan diabetic rabbits. Although MC extracts showed significant hypoglycaemic effects (p < 0.05), these did not result in normal glucose and lipid profile levels. Regeneration of pancreatic beta cells by MC extracts was minimal, with fractional improvement produced by glibenclamide.

ABSTRACT

Accepted: 
29 Oct, 2013
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Journal Sections: 
Journal Authors: 
e-Published: 08 May, 2014
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