In the study reported, macrophages, smooth muscle and endothelial arterial cells were challenged against different concentrations of 7-ketocholesterol in normoglycemic and high glucose conditions. The hyperglycaemic medium protects only smooth muscle artery cells against the cytotoxic effects of 7-ketocholesterol.

The microenvironment of multiple myeloma (MM), composed of different cells, is influenced by the massive presence of neoplastic plasma cells. Osteoblastic suppression and osteoclast induction is one of the tumour stimuli. Simvastatin protects osteoblasts from the deleterious effects of the liquid milieu of MM.