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Lipoxygenase Inhibitory Tetraketones

Lipoxygenase Inhibitory Tetraketones: Potential Remedial Source for Inflammation and Asthma

Twenty-one tetraketones were synthesized in high yields by condensation of cyclohexane-1, 3-dione with a variety of aldehydes in the presence of tetraethyl ammonium bromide (Et4N+Br¯) as catalyst under mild reaction conditions. Most of these compounds showed significant inhibitory activity against the enzyme lipoxygenase.


Objective: A series of tetraketones has been synthesized by way of a one pot synthesis and screened for inhibitory activity against the enzyme lipoxygenase.

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e-Published: 17 Sep, 2013
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