Morbidity and mortality rates of COPD are continuously increasing throughout the world. We aimed to determine factors associated with in-hospital-mortality of all causes following critical care admissions of patients with COPD. Features during admission to the ICU of patients were studied such as demographic and clinical features, laboratory analyses and comorbid diseases. Co-morbid diseases such as CHF, AF and postoperative care affect mortality the most in COPD patients who are hospitalized in ICU. Laboratory tests like creatinine and clinical features like being intubated upon admission, duration of mechanical ventilation and EF are other independent variables that affect mortality.