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Protective Effects of CAPE on Isoniazid and Rifampicin Induced Hepatic and Pancreatic Injury



Objective: To investigate the protective effects of against isoniazid (INH) and rifampicin (RFP)-induced hepatic and pancreatic damage.

Methods: Eighty adult rats were randomly divided into eight groups; Control; INH; RFP; INH+RFP; INH+CAPE; RFP+CAPE; INH+RFP+CAPE; CAPE. Both INH and RFP was orally administered for 30 days at a dose of 50mg/kg/day. CAPE was intraperitoneally injected for 30 days (10 μmol/kg). Blood samples, hepatic and pancreatic tissues were obtained on day 30.

Results: Total oxidant status levels were significantly higher in INH and/or RFP-treated groups than those of control and CAPE groups, while total antioxidant status and paraoxonase-1levels were significantly reduced in INH-RFP groups compared with the group receiving CAPE.

Histopathological deterioration was observed in RFP and INH groups in pancreatic and hepatic tissue. However, significant amelioration was observed in CAPE-treated groups.

Conclusion: Our findings suggest that CAPE may be a promising agent to prevent the side effects of INH and RFP treatment on hepatic and pancreatic tissues.

04 Jan, 2016
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e-Published: 30 Mar, 2016


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