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Protective Effects of Caffeic Acid Phenethyl Ester on Isoniazid and Rifampicin-induced Hepatic and Pancreatic Injury

Issue: 
DOI: 
10.7727/wimj.2015.561
Pages: 
350-5
Synopsis: 
This study investigated the protective effects of caffeic acid phenethyl ester (CAPE) against rifampicin-isoniazid-induced hepatic and pancreatictoxicity in terms of histopathological deterioration, oxidative stress (paraoxonase-1, total antioxidant status, total oxidant status) and biochemical parameters changes. The side effects of isoniazid and rifampicin treatment on hepatic and pancreatic tissues may be prevented with CAPE.

ABSTRACT

Objective: To investigate the protective effects of caffeic acid phenethyl ester (CAPE) against isoniazid (INH)- and rifampicin (RFP)-induced hepatic and pancreatic damage.

Accepted: 
04 Jan, 2016
PDF Attachment: 
Journal Sections: 
e-Published: 30 Mar, 2016

Non-alcoholic Fatty Liver Disease in a Jamaican Patient Population

Issue: 
DOI: 
10.7727/wimj.2015.349
Pages: 
557-60
Synopsis: 
Prevalence of NAFLD on abdominal ultrasound was 2.4%. Increased BMI was present in 85.5%. Risk factors identified were age, obesity, diabetes, and dyslipidaemia. Hepatomegaly was present in 10.7% of patients, elevated serum AST in 21.2% of patients tested and elevated ALT in 3.7%.

ABSTRACT

Objectives: This study determined the prevalence and clinical features of non-alcoholic fatty liver disease over a 6 year period in a patient population.

Methods: Patients diagnosed with fatty liver disease by ultrasound and/or liver biopsy between June 2006 to June 2012 at the University Hospital of the West Indies, Jamaica were reviewed.

Accepted: 
21 Aug, 2015
PDF Attachment: 
Journal Sections: 
e-Published: 28 Dec, 2015

Changes in Some Liver Enzymes in Streptozotocin-induced Diabetic Rats fed Sapogenin Extract from Bitter Yam (Dioscorea polygonoides) or Commercial Diosgenin

Issue: 
Pages: 
97–101
Synopsis: 
The consumption of sapogenin extract from bitter yam by diabetic rats results in changes in the metabolism of glucose with subsequent reduction in plasma glucose concentration.

                                                                      ABSTRACT

PDF Attachment: 
Journal Sections: 
e-Published: 05 Jun, 2013
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