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Protective Effects of CAPE on Isoniazid and Rifampicin Induced Hepatic and Pancreatic Injury

DOI: 
10.7727/wimj.2015.561
Synopsis: 
This study investigated the protective effects of caffeic acid phenethyl ester (CAPE) against rifampicin-isoniazid induced hepatic and pancreatic toxicity in terms of histopathological deterioration, oxidative stress (paraoxonase-1, total antioxidant status, Total oxidant status) and biochemical parameters changes. The side effects of INH and RFP treatment on hepatic and pancreatic tissues may be prevented with CAPE.

ABSTRACT

Objective: To investigate the protective effects of against isoniazid (INH) and rifampicin (RFP)-induced hepatic and pancreatic damage.

Accepted: 
04 Jan, 2016
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Journal Sections: 
e-Published: 30 Mar, 2016

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Non-alcoholic Fatty Liver Disease in a Jamaican Patient Population

Issue: 
DOI: 
10.7727/wimj.2015.349
Pages: 
557-60
Synopsis: 
Prevalence of NAFLD on abdominal ultrasound was 2.4%. Increased BMI was present in 85.5%. Risk factors identified were age, obesity, diabetes, and dyslipidaemia. Hepatomegaly was present in 10.7% of patients, elevated serum AST in 21.2% of patients tested and elevated ALT in 3.7%.

ABSTRACT

Objectives: This study determined the prevalence and clinical features of non-alcoholic fatty liver disease over a 6 year period in a patient population.

Methods: Patients diagnosed with fatty liver disease by ultrasound and/or liver biopsy between June 2006 to June 2012 at the University Hospital of the West Indies, Jamaica were reviewed.

Accepted: 
21 Aug, 2015
PDF Attachment: 
Journal Sections: 
e-Published: 28 Dec, 2015

Changes in Some Liver Enzymes in Streptozotocin-induced Diabetic Rats fed Sapogenin Extract from Bitter Yam (Dioscorea polygonoides) or Commercial Diosgenin

Issue: 
Pages: 
97–101
Synopsis: 
The consumption of sapogenin extract from bitter yam by diabetic rats results in changes in the metabolism of glucose with subsequent reduction in plasma glucose concentration.

                                                                      ABSTRACT

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Journal Sections: 
e-Published: 05 Jun, 2013
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