Liver

Protective Effects of Caffeic Acid Phenethyl Ester on Isoniazid and Rifampicin-induced Hepatic and Pancreatic Injury

Issue:

Vol 69, Issue 5: 2021

DOI:

10.7727/wimj.2015.561

Pages:

350-5

Synopsis:

This study investigated the protective effects of caffeic acid phenethyl ester (CAPE) against rifampicin-isoniazid-induced hepatic and pancreatictoxicity in terms of histopathological deterioration, oxidative stress (paraoxonase-1, total antioxidant status, total oxidant status) and biochemical parameters changes. The side effects of isoniazid and rifampicin treatment on hepatic and pancreatic tissues may be prevented with CAPE.

ABSTRACT

Objective: To investigate the protective effects of caffeic acid phenethyl ester (CAPE) against isoniazid (INH)- and rifampicin (RFP)-induced hepatic and pancreatic damage.

Received:

16 Nov, 2015

Accepted:

04 Jan, 2016

Published:

12 Nov, 2021

PDF Attachment:

wimj-iss5-2021_350_355.pdf

Journal Sections:

Original Articles

Keywords:

Caffeic acid phenethyl ester

Journal Authors:

e-Published: 30 Mar, 2016

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Non-alcoholic Fatty Liver Disease in a Jamaican Patient Population

Issue:

Vol 65, Issue 3: 2016

DOI:

10.7727/wimj.2015.349

Pages:

557-60

Synopsis:

Prevalence of NAFLD on abdominal ultrasound was 2.4%. Increased BMI was present in 85.5%. Risk factors identified were age, obesity, diabetes, and dyslipidaemia. Hepatomegaly was present in 10.7% of patients, elevated serum AST in 21.2% of patients tested and elevated ALT in 3.7%.

ABSTRACT

Objectives: This study determined the prevalence and clinical features of non-alcoholic fatty liver disease over a 6 year period in a patient population.

Methods: Patients diagnosed with fatty liver disease by ultrasound and/or liver biopsy between June 2006 to June 2012 at the University Hospital of the West Indies, Jamaica were reviewed.

Received:

25 Jun, 2015

Accepted:

21 Aug, 2015

PDF Attachment:

wimj_iss3_2016_557_560.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 28 Dec, 2015

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Changes in Some Liver Enzymes in Streptozotocin-induced Diabetic Rats fed Sapogenin Extract from Bitter Yam (Dioscorea polygonoides) or Commercial Diosgenin

Issue:

Vol 54, Issues 2 (2005)

Pages:

97–101

Synopsis:

The consumption of sapogenin extract from bitter yam by diabetic rats results in changes in the metabolism of glucose with subsequent reduction in plasma glucose concentration.

ABSTRACT

PDF Attachment:

mcanuff_changes_in_some_liver_enzymes.pdf

Journal Sections:

Keywords:

Streptozotocin-induced Diabetic Rats

Sapogenin

Extract from Bitter Yam (Dioscorea polygonoides) or commercial diosgenin